GTR Home > Conditions/Phenotypes > Parkinson disease 6, autosomal recessive early-onset

Summary

Excerpted from the GeneReview: PINK1 Type of Young-Onset Parkinson Disease
PINK1 type of young-onset Parkinson disease is characterized by early onset (mean age 33 years) of tremor, bradykinesia, and rigidity that are often indistinguishable from other causes of Parkinson disease. Lower-limb dystonia may be a presenting sign. Postural instability, hyperreflexia, abnormal behavior, and psychiatric manifestations have been described. The disease is usually slowly progressive. Individuals have a marked and sustained response to oral administration of levodopa (L-dopa), frequently associated with L-dopa-induced fluctuations and dyskinesias.

Genes See tests for all associated and related genes

  • Also known as: BRPK, PARK6, PINK1
    Summary: PTEN induced kinase 1

Clinical features

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