GTR Home > Conditions/Phenotypes > Ischemic stroke

Summary

A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. It is said to be the third leading cause of death in the United States. Gunel and Lifton (1996) noted that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic strokes, resulting from vascular occlusion, account for the majority of strokes. Bersano et al. (2008) reviewed genetic polymorphisms that have been implicated in the development of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; 612309), the renin-angiotensin-aldosterone system (see, e.g., ACE; 106180), homocysteine (see, e.g., MTHFR; 607093), and lipoprotein metabolism (see, e.g., APOE; 107741). See also hemorrhagic stroke, or intracerebral hemorrhage (ICH; 614519). [from OMIM]

Available tests

20 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Genes See tests for all associated and related genes

  • Also known as: FLAP, ALOX5AP
    Summary: arachidonate 5-lipoxygenase activating protein

  • Also known as: PT, RPRGL2, THPH1, F2
    Summary: coagulation factor II, thrombin

  • Also known as: FVL, PCCF, RPRGL1, THPH2, F5
    Summary: coagulation factor V

  • Also known as: ECNOS, eNOS, NOS3
    Summary: nitric oxide synthase 3

  • Also known as: PKC-L, PKCL, PRKCL, nPKC-eta, PRKCH
    Summary: protein kinase C eta

Clinical features

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Practice guidelines

  • AHA/ASA, 2014
    Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

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