GTR Home > Conditions/Phenotypes > Hereditary pancreatitis

Summary

Excerpted from the GeneReview: PRSS1-Related Hereditary Pancreatitis
PRSS1-related hereditary pancreatitis (HP) is characterized by episodes of acute pancreatitis (AP) and recurrent acute pancreatitis (RAP: >1 episode of AP), with frequent progression to chronic pancreatitis (CP). Manifestations of acute pancreatitis can range from vague abdominal pain lasting one to three days to severe abdominal pain lasting days to weeks and requiring hospitalization.

Genes See tests for all associated and related genes

  • Also known as: ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, CFTR
    Summary: CF transmembrane conductance regulator

  • Also known as: CLCR, ELA4, CTRC
    Summary: chymotrypsin C

  • Also known as: TRP1, TRY1, TRY4, TRYP1, PRSS1
    Summary: serine protease 1

  • Also known as: TRY2, TRY8, TRYP2, PRSS2
    Summary: serine protease 2

  • Also known as: PCTT, PSTI, Spink3, TATI, TCP, SPINK1
    Summary: serine peptidase inhibitor, Kazal type 1

Clinical features

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