GTR Home > Conditions/Phenotypes > Essential hypertension


The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations. [from OMIM]

Available tests

22 tests are in the database for this condition.

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Genes See tests for all associated and related genes

  • Also known as: ADDA, ADD1
    Summary: adducin 1

  • Also known as: ANHU, SERPINA8, hFLT1, AGT
    Summary: angiotensinogen

  • Also known as: AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, AGTR1
    Summary: angiotensin II receptor type 1

  • Also known as: ATP1B, ATP1B1
    Summary: ATPase Na+/K+ transporting subunit beta 1

  • Also known as: CP35, CYPIIIA5, P450PCN3, PCN3, CYP3A5
    Summary: cytochrome P450 family 3 subfamily A member 5

  • Also known as: ECE, ECE1
    Summary: endothelin converting enzyme 1

  • Also known as: CSNB1H, GNB3
    Summary: G protein subunit beta 3

  • Also known as: HEP-NOS, INOS, NOS, NOS2A, NOS2
    Summary: nitric oxide synthase 2

  • Also known as: ECNOS, eNOS, NOS3
    Summary: nitric oxide synthase 3

  • Also known as: CYP8, CYP8A1, PGIS, PTGI, PTGIS
    Summary: prostaglandin I2 synthase

  • Also known as: MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, RGS5
    Summary: regulator of G protein signaling 5

Clinical features


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