GTR Home > Conditions/Phenotypes > Osteosarcoma


A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor. [from HPO]

Genes See tests for all associated and related genes

  • Also known as: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, CHEK2
    Summary: checkpoint kinase 2

  • Also known as: OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1
    Summary: RB transcriptional corepressor 1

  • Also known as: BCC7, LFS1, P53, TRP53, TP53
    Summary: tumor protein p53

Clinical features


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