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    inx-19 Innexin-19 [ Caenorhabditis elegans ]

    Gene ID: 171805, updated on 11-Apr-2024

    Summary

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    Gene symbol
    inx-19
    Gene description
    Innexin-19
    Primary source
    WormBase:WBGene00002141
    Locus tag
    CELE_T16H5.1
    See related
    AllianceGenome:WB:WBGene00002141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables calcium channel inhibitor activity; gap junction hemi-channel activity; and protein kinase inhibitor activity. Involved in determination of left/right asymmetry in nervous system; intercellular transport; and negative regulation of cation channel activity. Located in gap junction and neuronal cell body membrane. Is expressed in several structures, including ADA; K' cell; ganglia; hermaphrodite distal tip cell; and pharyngeal neurons. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (2451898..2463461, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Transmembrane protein 50A Neighboring gene ABC transmembrane type-1 domain-containing protein Neighboring gene Conserved secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans. Voelker L, et al. PLoS Genet, 2019 Oct. PMID 31658255, Free PMC Article
    2. The microRNA mir-71 inhibits calcium signaling by targeting the TIR-1/Sarm1 adaptor protein to control stochastic L/R neuronal asymmetry in C. elegans. Hsieh YW, et al. PLoS Genet, 2012. PMID 22876200, Free PMC Article
    3. Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans. Mutlu AS, et al. Nat Commun, 2020 Mar 19. PMID 32193370, Free PMC Article
    4. Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system. Starich TA, et al. Neural Dev, 2009 May 11. PMID 19432959, Free PMC Article
    5. Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans. Chang C, et al. Development, 2011 Aug. PMID 21771813, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gap junction hemi-channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of left/right asymmetry in nervous system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intercellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin-19
    NP_001367775.1
    • Confirmed by transcript evidence
    NP_490983.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2451898..2463461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381412.2 → NP_001367775.1  Innexin-19 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00876
      Location:22 → 397
      Innexin

    2. NM_058582.8 → NP_490983.2  Innexin-19 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490983.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61715, Q86S34
      Conserved Domains (1) summary
      pfam00876
      Location:37 → 414
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61715.2

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