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    TRIM5 tripartite motif containing 5 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574288, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TRIM5provided by VGNC
    Official Full Name
    tripartite motif containing 5provided by VGNC
    Primary source
    VGNC:VGNC:106441
    See related
    Ensembl:ENSMMUG00000000335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (62539688..62568289)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (61451334..61478845)

    Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 52H1-like Neighboring gene tripartite motif containing 22 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene tripartite motif containing 34 Neighboring gene uncharacterized LOC106993361

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α. Imam S, et al. J Virol, 2019 Jul 15. PMID 31068426, Free PMC Article
    2. Dynamic regulation of HIV-1 capsid interaction with the restriction factor TRIM5α identified by magic-angle spinning NMR and molecular dynamics simulations. Quinn CM, et al. Proc Natl Acad Sci U S A, 2018 Nov 6. PMID 30333189, Free PMC Article
    3. Rhesus monkey TRIM5α protein SPRY domain contributes to AP-1 activation. Na L, et al. J Biol Chem, 2018 Feb 23. PMID 29196608, Free PMC Article
    4. Targeting the rhesus macaque TRIM5α gene to enhance the susceptibility of CD4(+) T cells to HIV-1 infection. Wang X, et al. Arch Virol, 2017 Mar. PMID 27888407
    5. Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction. Lamichhane R, et al. Virology, 2017 Jan. PMID 27821283, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a noncanonical role for K63-linked ubiquitin in the process of retroviral restriction by TRIM5alpha and potentially providing insight into the mechanism of action of other TRIM family proteins.
      Title: K63-Linked Ubiquitin Is Required for Restriction of HIV-1 Reverse Transcription and Capsid Destabilization by Rhesus TRIM5α.
    2. Dynamic regulation of HIV-1 capsid interaction with the restriction factor TRIM5alpha has been reported.
      Title: Dynamic regulation of HIV-1 capsid interaction with the restriction factor TRIM5α identified by magic-angle spinning NMR and molecular dynamics simulations.
    3. Data suggest that SPRY domain of TRIM5a is essential in activation of AP-1 signaling but not NF-kappaB signaling in this species. (TRIM5a = tripartite motif-containing 5 alpha isoenzyme; AP-1 = activator 1 protein)
      Title: Rhesus monkey TRIM5α protein SPRY domain contributes to AP-1 activation.
    4. High resolution crystal structure of a Trim5Alpha dimeric Bbox domain.
      Title: Crystal structure of the Trim5α Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface.
    5. L2 region of the TRIM5alpha dimer undergoes dynamic conformational changes, which results in the displacement of L2 regions by 25 angstroms relative to each other.
      Title: Dynamic conformational changes in the rhesus TRIM5α dimer dictate the potency of HIV-1 restriction.
    6. HIV-1 virus target the rhTRIM5alpha enhanced the susceptibility to HIV-1 infection.
      Title: Targeting the rhesus macaque TRIM5α gene to enhance the susceptibility of CD4(+) T cells to HIV-1 infection.
    7. Mutations in gag and pol are associated with escape of HIV-1 from rhTrim5alpha.
      Title: Adaptation of HIV-1 to rhTrim5α-mediated restriction in vitro.
    8. These studies provide direct evidence that ubiquitin conjugation to rhTRIM5alpha-containing complexes is required for inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.
      Title: TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.
    9. These results confirm that the SUMO machinery is involved in TRIM5alpha-mediated retroviral restriction, and demonstrate that TRIM5alpha is a SUMO 1 and SUMO 2 substrate.
      Title: TRIM5α is a SUMO substrate.
    10. These data show that there could be some distinct HIV-1 capsid patterns to confer significant resistance to rhesus TRIM5-alpha.
      Title: Distinct combinations of amino acid substitutions in N-terminal domain of Gag-capsid afford HIV-1 resistance to rhesus TRIM5α.
    Submit: New GeneRIF Correction See all GeneRIFs (49)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tripartite motif-containing protein 5
    Names
    RING-type E3 ubiquitin transferase TRIM5
    TRIM5alpha
    tripartite motif-containing 5/cyclophilin A fusion protein
    NP_001028082.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032910.1 → NP_001028082.1  tripartite motif-containing protein 5

      See identical proteins and their annotated locations for NP_001028082.1

      Status: PROVISIONAL

      Source sequence(s)
      AY523632
      UniProtKB/Swiss-Prot
      Q0PF16, Q0PF17, Q2YEN1, Q6GX25, Q6QWE9, Q6QWF0
      UniProtKB/TrEMBL
      A1E963
      Related
      ENSMMUP00000050746.2, ENSMMUT00000065274.2
      Conserved Domains (3) summary
      smart00336
      Location:92 → 133
      BBOX; B-Box-type zinc finger
      cd00162
      Location:14 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15822
      Location:290 → 493
      SPRY_PRY_TRIM5; PRY/SPRY domain in tripartite motif-binding protein 5 (TRIM5), also known as RING finger protein 88 (RNF88)

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041767.1 Reference Mmul_10 Primary Assembly

      Range
      62539688..62568289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0PF16.2 GenPept UniProtKB/Swiss-Prot:Q0PF16

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