CAD1 MAC/Perforin domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: CAD1
Gene description: MAC/Perforin domain-containing protein
Primary source: Araport:AT1G29690
Locus tag: AT1G29690
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: constitutively activated cell death 1; F15D2.24; F15D2_24; necrotic spotted lesion 2; NSL2
Summary: Encodes a protein containing a domain with significant homology to the MACPF (membrane attack complex and perforin) domain of complements and perforin proteins that are involved in innate immunity in animals. Transgenic <i>cad1-1</i> mutant plants show lesions seen in the hypersensitive response, as well as a spontaneous activation of expression of pathogenesis-related genes and leading to a 32-fold increase in salicylic acid (SA). CAD1 is postulated to act as a negative regulator controlling SA-mediated pathway of programmed cell death in plant immunity.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_102709.4

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of salicylic acid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of salicylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

NP_564333.1

constitutively activated cell death 1 (CAD1); CONTAINS InterPro DOMAIN/s: Membrane attack complex component/perforin (MACPF) domain (InterPro:IPR020864); BEST Arabidopsis thaliana protein match is: MAC/Perforin domain-containing protein (TAIR:AT4G24290.2); Has 226 Blast hits to 225 proteins in 30 species: Archae - 0; Bacteria - 6; Metazoa - 14; Fungi - 0; Plants - 200; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).