LPAR6 lysophosphatidic acid receptor 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LPAR6provided by HGNC
Official Full Name: lysophosphatidic acid receptor 6provided by HGNC
Primary source: HGNC:HGNC:15520
See related: Ensembl:ENSG00000139679 MIM:609239; AllianceGenome:HGNC:15520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAH3; P2Y5; ARWH1; HYPT8; LPA-6; P2RY5
Summary: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Expression: Ubiquitous expression in placenta (RPKM 27.8), fat (RPKM 19.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (48389571..48444669, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (47609888..47664937, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (48985274..49018805, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.
Title: Cell-trafficking impairment in disease-associated LPA6 missense mutants and a potential pharmacoperone therapy for autosomal recessive woolly hair/hypotrichosis.
Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma.
Title: Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma.
Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene.
Title: Autosomal recessive woolly hair and hypotrichosis in two Caucasian dizygotic twins. Description of a novel biallelic mutation in the LPAR6 gene.
A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.
Title: A distinctive protein signature induced by lysophosphatidic acid receptor 6 (LPAR6) expression in hepatocellular carcinoma cells.
A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.
Title: A potential target for liver cancer management, lysophosphatidic acid receptor 6 (LPAR6), is transcriptionally up-regulated by the NCOA3 coactivator.
Study revealed a novel homozygous missense mutation c.47A>T (p.Lys16Met) in the LPAR6 gene in Pakistani family with autosomal recessive wooly hair/hypotrichosis.
Title: Biallelic mutations in the LPAR6 gene causing autosomal recessive wooly hair/hypotrichosis phenotype in five Pakistani families.
LPAR6 was downregulated in breast cancer(BC), and low LPAR6 expression was related to poor prognosis. The anti-tumor drug 5-Aza significantly upregulated LPAR6 expression in vitro, and LPAR6 might act as a tumor suppressor in BC.
Title: Lysophosphatidic Acid Receptor 6 (LPAR6) Expression and Prospective Signaling Pathway Analysis in Breast Cancer.
mRNA expression analyses revealed that ADSCs and MES largely expressed LPA receptor 1 (LPAR1) while epithelial cells mainly expressed LPAR6. LPA 18:1 activated all the cell populations and cell lines by rise in cytosolic free calcium concentrations. MES and ADSCs expressed ATX whereas epithelial cells did not.
Title: ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro.
Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in three consanguineous Pakistani families.
Title: Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair/hypotrichosis in consanguineous families.
DLD-C-F cells formed large-sized colonies, but not DLD-F-C cells, correlating with LPAR1 and LPAR6 gene expression levels. These results suggest that LPA1 and LPA6 may regulate the colony formation activity in DLD1 cells treated with anticancer drugs.
Title: Effects of LPA(1) and LPA(6) on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hypotrichosis 8 MedGen: C3279470 OMIM: 278150 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17879 (e-PCR)
- UniSTS:7010

NoName (e-PCR)
- UniSTS:484469

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in blastocyst hatching	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 6

Names: G-protein coupled purinergic receptor P2Y5; LPA receptor 6; P2Y purinoceptor 5; RB intron encoded G-protein coupled receptor; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic receptor 5; purinergic receptor P2Y G protein-coupled protein 5; purinergic receptor P2Y, G-protein coupled, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012874.2 RefSeqGene

Range

36556..38531

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001162497.3 → NP_001155969.1 lysophosphatidic acid receptor 6

See identical proteins and their annotated locations for NP_001155969.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AL136960, AL392048

Consensus CDS

CCDS9410.1

UniProtKB/Swiss-Prot

A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

UniProtKB/TrEMBL

B3KVQ5

Related

ENSP00000344353.2, ENST00000345941.2

Conserved Domains (1) summary

cd15156
Location:18 → 302

7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001162498.3 → NP_001155970.1 lysophosphatidic acid receptor 6

See identical proteins and their annotated locations for NP_001155970.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AL392048

Consensus CDS

CCDS9410.1

UniProtKB/Swiss-Prot

A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

UniProtKB/TrEMBL

B3KVQ5

Related

ENSP00000482660.1, ENST00000620633.5

Conserved Domains (1) summary

cd15156
Location:18 → 302

7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001377316.2 → NP_001364245.1 lysophosphatidic acid receptor 6

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AL136960, AL392048

Consensus CDS

CCDS9410.1

UniProtKB/Swiss-Prot

A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

UniProtKB/TrEMBL

B3KVQ5

Conserved Domains (1) summary

cd15156
Location:18 → 302

7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001377317.2 → NP_001364246.1 lysophosphatidic acid receptor 6

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AL136960, AL392048

Consensus CDS

CCDS9410.1

UniProtKB/Swiss-Prot

A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

UniProtKB/TrEMBL

B3KVQ5

Conserved Domains (1) summary

cd15156
Location:18 → 302

7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_005767.7 → NP_005758.2 lysophosphatidic acid receptor 6

See identical proteins and their annotated locations for NP_005758.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.

Source sequence(s)

AL136960, AL392048

Consensus CDS

CCDS9410.1

UniProtKB/Swiss-Prot

A4FTW9, B3KVF2, F2YGU4, O15133, P43657, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6

UniProtKB/TrEMBL

B3KVQ5

Related

ENSP00000367691.3, ENST00000378434.8

Conserved Domains (1) summary

cd15156
Location:18 → 302

7tmA_LPAR6_P2Y5; lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors