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    Cenpa centromere protein A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298850, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cenpaprovided by RGD
    Official Full Name
    centromere protein Aprovided by RGD
    Primary source
    RGD:1563607
    See related
    Ensembl:ENSRNOG00000032178 AllianceGenome:RGD:1563607
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563607
    Summary
    Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; kinetochore assembly; and protein localization to chromosome, centromeric region. Predicted to be located in kinetochore; nucleoplasm; and pericentric heterochromatin. Predicted to be part of inner kinetochore and nucleosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human CENPA (centromere protein A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 95.9), Spleen (RPKM 63.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (31420062..31431703, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25700142..25711767, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (27072259..27080863, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase-like 5 Neighboring gene uncharacterized LOC120103488 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC134479331 Neighboring gene solute carrier family 35, member F6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hepatitis B virus X protein mutant upregulates CENP-A expression in hepatoma cells. Liu L, et al. Oncol Rep, 2012 Jan. PMID 21956590
    2. Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. Muro Y, et al. Clin Exp Immunol, 2000 Apr. PMID 10759786, Free PMC Article
    3. The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity. Roulland Y, et al. Mol Cell, 2016 Aug 18. PMID 27499292
    4. ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. De La Fuente R, et al. Dev Biol, 2004 Aug 1. PMID 15242786
    5. Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading. Kim IS, et al. Mol Cell, 2012 May 11. PMID 22516971

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CENP-A containing chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CENP-A containing nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone H3-like centromeric protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106711.1 → NP_001100181.1  histone H3-like centromeric protein A

      See identical proteins and their annotated locations for NP_001100181.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HAC7, B2RZ23, F7EQM2
      Conserved Domains (3) summary
      smart00428
      Location:59 → 156
      H3; Histone H3
      pfam00125
      Location:29 → 152
      Histone; Core histone H2A/H2B/H3/H4
      pfam15091
      Location:5 → 73
      DUF4554; Domain of unknown function (DUF4554)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      31420062..31431703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239798.5 → XP_006239860.1  histone H3-like centromeric protein A isoform X1

      See identical proteins and their annotated locations for XP_006239860.1

      UniProtKB/TrEMBL
      A6HAC7, B2RZ23, F7EQM2
      Related
      ENSRNOP00000012512.3
      Conserved Domains (3) summary
      smart00428
      Location:59 → 156
      H3; Histone H3
      pfam00125
      Location:29 → 152
      Histone; Core histone H2A/H2B/H3/H4
      pfam15091
      Location:5 → 73
      DUF4554; Domain of unknown function (DUF4554)

    2. XM_017594068.3 → XP_017449557.1  histone H3-like centromeric protein A isoform X2

      UniProtKB/TrEMBL
      A6HAC8
    Nucleotide Protein Strain
    Heading Accession and Version

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