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    AMA1 Ama1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853140, updated on 11-Apr-2024

    Summary

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    Gene symbol
    AMA1
    Gene description
    Ama1p
    Primary source
    SGD:S000003457
    Locus tag
    YGR225W
    See related
    AllianceGenome:SGD:S000003457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPO70
    Summary
    Enables ubiquitin ligase activator activity. Involved in several processes, including ascospore wall assembly; positive regulation of cellular protein metabolic process; and regulation of cell cycle process. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (945145..947019)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Hsv2p Neighboring gene azole transporter Neighboring gene dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase Neighboring gene Oto1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A subset of Mer1p-dependent introns requires Bud13p for splicing activation and nuclear retention. Scherrer FW Jr, et al. RNA, 2006 Jul. PMID 16738408, Free PMC Article
    2. The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. Omerza G, et al. Mol Biol Cell, 2018 Jan 1. PMID 29118076, Free PMC Article
    3. SPO71 encodes a developmental stage-specific partner for Vps13 in Saccharomyces cerevisiae. Park JS, et al. Eukaryot Cell, 2013 Nov. PMID 24036347, Free PMC Article
    4. The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae. Diamond AE, et al. Mol Biol Cell, 2009 Jan. PMID 18946082, Free PMC Article
    5. Aurora B-dependent Ndc80 degradation regulates kinetochore composition in meiosis. Chen J, et al. Genes Dev, 2020 Feb 1. PMID 31919192, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic dissection of prospore membrane closure finds SPS1 and SPO77 act in parallel to a previously described pathway of prospore membrane closure that involves AMA1, an activator of the meiotic anaphase promoting complex.
      Title: Timely Closure of the Prospore Membrane Requires SPS1 and SPO77 in Saccharomyces cerevisiae.
    2. Study shows that an extended prophase I additionally requires the suppression of latent, mitotic cell-cycle controls by the anaphase-promoting complex (APC/C) and its meiosis-specific activator Ama1, which trigger the degradation of M phase regulators and Ndd1, a subunit of a mitotic transcription factor.
      Title: Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.
    3. These results demonstrate that APC(Ama1) functions to coordinate the exit from meiosis II with cytokinesis.
      Title: The anaphase promoting complex targeting subunit Ama1 links meiotic exit to cytokinesis during sporulation in Saccharomyces cerevisiae.
    4. Cdc28 and Ama1 function in a pathway to trigger Smk1-dependent steps in spore morphogenesis.
      Title: The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast.
    5. Chromosome segregation in meiosis depends on the selective inhibition of a meiosis-specific form of the APC/C-Ama1.
      Title: The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin ligase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ascospore formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA integrity checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ascospore-type prospore membrane formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ama1p
    NP_011741.5
    • Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      945145..947019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181354.3 → NP_011741.5  TPA: Ama1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011741.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV07, P50082, Q96VQ3
      UniProtKB/TrEMBL
      C7GNK2, N1P2K4
      Conserved Domains (2) summary
      sd00039
      Location:328 → 374
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:266 → 561
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50082.2

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