Angpt2 angiopoietin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angpt2provided by MGI
Official Full Name: angiopoietin 2provided by MGI
Primary source: MGI:MGI:1202890
See related: Ensembl:ENSMUSG00000031465 AllianceGenome:MGI:1202890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ang2; Agpt2; Ang-2
Summary: This gene encodes an endothelial cell (EC)-derived regulator of angiogenesis and ligand for endothelial-specific receptor tyrosine kinase. The encoded protein acts as an anti-apoptotic factor for stressed ECs and a proapoptotic factor for resting ECs. [provided by RefSeq, Jan 2013]
Expression: Broad expression in placenta adult (RPKM 8.9), kidney adult (RPKM 5.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.3; 8 10.3 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (18740279..18791578, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (18690263..18741562, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia-Inducible Factor-1alpha in SM22alpha-Expressing Cells Modulates Alveolarization.
Title: Hypoxia-Inducible Factor-1α in SM22α-Expressing Cells Modulates Alveolarization.
ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.
Title: ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.
Angiopoietin-2 Promotes Mechanical Stress-induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF-1alpha/NF-kappaB Signaling Pathway.
Title: Angiopoietin-2 Promotes Mechanical Stress-induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF-1α/NF-κB Signaling Pathway.
Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance.
Title: Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance.
Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization.
Title: Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization.
Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients.
Title: Blood angiopoietin-2 predicts liver angiogenesis and fibrosis in hepatitis C patients.
Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.
Title: Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.
Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Title: Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Angiopoietin-2-integrin alpha5beta1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance.
Title: Angiopoietin-2-integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance.
Disease activity was significantly increased in Ang2 knockout mice compared with wild-type and heterozygote mice. Lymphatic deficiency, defective lymphangiogenesis, and impaired lymphatic-generated inflammation did not protect against clinical Inflammatory bowel disease (IBD) or progression to colorectal cancer in this experimental model.
Title: Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Angpt2 (e-PCR), detects polymorphism
- UniSTS:498459

Angpt2 (e-PCR), detects polymorphism
- UniSTS:498722

Angpt2 (e-PCR), detects polymorphism
- UniSTS:471086

PMC314347P1 (e-PCR)
- UniSTS:272943

Angpt2 (e-PCR), detects polymorphism
- UniSTS:545846

NoName (e-PCR)
- UniSTS:235845

D8Ertd51e (e-PCR), detects polymorphism
- UniSTS:167576

Angpt2 (e-PCR), detects polymorphism
- UniSTS:526066

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor antagonist activity	TAS Traceable Author Statement more info	PubMed
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Tie signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Tie signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Tie signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Tie signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within endoderm development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in glomerulus vasculature development	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.