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    SMC6 DNA repair protein SMC6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851099, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SMC6
    Gene description
    DNA repair protein SMC6
    Primary source
    SGD:S000004375
    Locus tag
    YLR383W
    See related
    AllianceGenome:SGD:S000004375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RHC18
    Summary
    Enables damaged DNA binding activity. Contributes to SUMO transferase activity. Involved in DNA double-strand break attachment to nuclear envelope; DNA recombination; and chromosome separation. Located in nucleus and site of double-strand break. Part of Smc5-Smc6 complex. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (885288..888632)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ctf3p Neighboring gene leucine--tRNA ligase NAM2 Neighboring gene Elongator subunit IKI3 Neighboring gene Swc7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Smc5/6 complex is a DNA loop-extruding motor. Pradhan B, et al. Nature, 2023 Apr. PMID 37076626, Free PMC Article
    2. Cryo-EM structure of the Smc5/6 holo-complex. Hallett ST, et al. Nucleic Acids Res, 2022 Sep 9. PMID 35993814, Free PMC Article
    3. A touching moment for Smc5/6: from ssDNA binding to repair. Ohouo PY, et al. Cell Cycle, 2011 Apr 15. PMID 21436624
    4. Anaphase onset before complete DNA replication with intact checkpoint responses. Torres-Rosell J, et al. Science, 2007 Mar 9. PMID 17347440
    5. Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. De Piccoli G, et al. Nat Cell Biol, 2006 Sep. PMID 16892052, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Smc5/6 complex is a DNA loop-extruding motor.
      Title: The Smc5/6 complex is a DNA loop-extruding motor.
    2. Cryo-EM structure of the Smc5/6 holo-complex.
      Title: Cryo-EM structure of the Smc5/6 holo-complex.
    3. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
      Title: Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
    4. Smc5/6 in the rDNA modulates lifespan independently of Fob1.
      Title: Smc5/6 in the rDNA modulates lifespan independently of Fob1​.
    5. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
      Title: Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
    6. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
      Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    7. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
      Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    8. Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
      Title: Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
    9. Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
      Title: Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites.
    10. Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
      Title: Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break attachment to nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of DNA recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA repair protein SMC6
    NP_013487.1
    • Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      885288..888632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182272.1 → NP_013487.1  TPA: DNA repair protein SMC6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ18, Q12749
      UniProtKB/TrEMBL
      A0A8H4BXH7, A7A1Q8, G2WJJ8, N1P1S0
      Conserved Domains (1) summary
      COG1196
      Location:81 → 1101
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12749.1

    Gene LinkOut

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