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    BUB2 Bub2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855077, updated on 13-Apr-2024

    Summary

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    Gene symbol
    BUB2
    Gene description
    Bub2p
    Primary source
    SGD:S000004659
    Locus tag
    YMR055C
    See related
    AllianceGenome:SGD:S000004659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAC7
    Summary
    Contributes to GTPase activator activity. Involved in mitotic spindle orientation checkpoint signaling and negative regulation of protein localization to mitotic spindle pole body. Located in spindle pole body. Part of Bfa1-Bub2 complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (386101..387021, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Stb2p Neighboring gene H(+)-transporting V0 sector ATPase subunit a Neighboring gene ADP/ATP carrier protein AAC1 Neighboring gene ferroxidase FET3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anaphase spindle position is monitored by the BUB2 checkpoint. Bloecher A, et al. Nat Cell Biol, 2000 Aug. PMID 10934478
    2. APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Visintin C, et al. Genes Dev, 2008 Jan 1. PMID 18172166, Free PMC Article
    3. Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Hu F, et al. Cell Cycle, 2002 Sep-Oct. PMID 12461298
    4. Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complex. Pereira G, et al. EMBO J, 2001 Nov 15. PMID 11707407, Free PMC Article
    5. Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5. Lee SE, et al. Curr Biol, 2001 May 15. PMID 11378390

    See all (163) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that spindle checkpoint factors Bub1 and Bub2 are recruited to the site of DNA damage.
      Title: Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining.
    2. regulation of cytokinesis and septation in budding yeast by Bub2.
      Title: Bub2 regulation of cytokinesis and septation in budding yeast.
    3. there is a GAP-independent surveillance mechanism of Bfa1/Bub2, which, together with the GTP/GDP switch of Tem1, may be required for the genomic stability of cells with misaligned spindles
      Title: Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.
    4. Bub2 disappearance from the mother bound spindle pole body at the onset of anaphase, along with Cdc5 function, helps prompt Tem1 activation in telophase.
      Title: Disappearance of the budding yeast Bub2-Bfa1 complex from the mother-bound spindle pole contributes to mitotic exit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle orientation checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to mitotic spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of septation initiation signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Bfa1-Bub2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Bfa1-Bub2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bub2p
    NP_013771.1
    • Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      386101..387021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182553.1 → NP_013771.1  TPA: Bub2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZN0, P26448
      UniProtKB/TrEMBL
      A0A6A5PST9, A6ZMB5, B3LLU9, C7GL68, C8ZEQ8, G2WKA4, N1NX79
      Conserved Domains (1) summary
      COG5210
      Location:1 → 304
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26448.1

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