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    AGA1 Aga1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855780, updated on 3-Dec-2023

    Summary

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    Gene symbol
    AGA1
    Gene description
    Aga1p
    Primary source
    SGD:S000005327
    Locus tag
    YNR044W
    See related
    AllianceGenome:SGD:S000005327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cell adhesion molecule binding activity. Involved in agglutination involved in conjugation with cellular fusion. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (703699..705876)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene diphosphomevalonate decarboxylase MVD1 Neighboring gene Pet494p Neighboring gene RNA methylation protein TRM112

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AGA1 product is involved in cell surface attachment of the Saccharomyces cerevisiae cell adhesion glycoprotein a-agglutinin. Roy A, et al. Mol Cell Biol, 1991 Aug. PMID 2072914, Free PMC Article
    2. Sexual agglutination in budding yeasts: structure, function, and regulation of adhesion glycoproteins. Lipke PN, et al. Microbiol Rev, 1992 Mar. PMID 1579109, Free PMC Article
    3. An efficient and simple method to increase the level of displayed protein on the yeast cell surface. Zhao JZ, et al. J Microbiol Methods, 2017 Apr. PMID 28188810
    4. Construction of an in vitro trans-sialylation system: surface display of Corynebacterium diphtheriae sialidase on Saccharomyces cerevisiae. Kim S, et al. Appl Microbiol Biotechnol, 2010 Oct. PMID 20711574
    5. Delineation of functional regions within the subunits of the Saccharomyces cerevisiae cell adhesion molecule a-agglutinin. Shen ZM, et al. J Biol Chem, 2001 May 11. PMID 11278672

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in agglutination involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aga1p
    NP_014442.1
    • Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      703699..705876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183221.1 → NP_014442.1  TPA: Aga1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1L9, P32323
      UniProtKB/TrEMBL
      A0A8H4BW01, C7GLL3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32323.1

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