MPS3 Mps3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: MPS3
Gene description: Mps3p
Primary source: SGD:S000003556
Locus tag: YJL019W
See related: AllianceGenome:SGD:S000003556
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NEP98; YJL018W
Summary: Predicted to enable protein-membrane adaptor activity. Involved in several processes, including chromosome organization; nuclear migration involved in conjugation with cellular fusion; and spindle pole body duplication. Located in chromosome, telomeric region; half bridge of spindle pole body; and nucleus. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (402897..404945)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis.
Title: Phosphorylation of luminal region of the SUN-domain protein Mps3 promotes nuclear envelope localization during meiosis.
Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
Title: Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
Cdh1, a coactivator of APC/C, modulates Mps3 stability. APC/C controls Mps3 degradation through Mps3's N terminus, which resides in the nucleoplasm and possesses two putative APC/C-dependent destruction motifs.
Title: The anaphase-promoting complex regulates the degradation of the inner nuclear membrane protein Mps3.
the response to a secretory defect required SUN protein Mps3, which was localized at the nuclear envelope and involved in spindle pole body assembly
Title: Arp2/3 complex and Mps3 are required for regulation of ribosome biosynthesis in the secretory stress response.
We show that noncleavable Mps3 (Mps3-nc) inhibits centrosome separation during yeast meiosis. In addition, overexpression of mps3-nc in vegetative yeast cells also inhibits centrosome separation and is lethal
Title: Cleavage of the SUN-domain protein Mps3 at its N-terminus regulates centrosome disjunction in budding yeast meiosis.
Mps2-Bbp1 directly interacts with Mps3 and Ndc1. We then purified Spc29 and reconstituted the ternary Mps2-Bbp1-Spc29 complex, proving that Bbp1 can simultaneously interact with Mps2 and Spc29 and in this way link the central plaque of the spindle pole body to the nuclear envelope
Title: A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast.
TFIIIC and Mps3 together direct the intranuclear positioning of a new class of S. cerevisiae genomic loci positioned at the nuclear periphery.
Title: TFIIIC localizes budding yeast ETC sites to the nuclear periphery.
Acetylation of Mps3 by Eco1 is one of the few regulatory mechanisms known to control nuclear organization.
Title: Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization.
we propose that Mps3 facilitates insertion of SPBs(spindle pole body) in the nuclear membrane by modulating nuclear envelope composition.
Title: The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.
These findings suggest that in meiosis, the Mps3 SUN domain is important for modulating chromosome motion events that act in meiotic chromosome juxtaposition and by extension, promoting proper morphogenesis of the synaptonemal complex.
Title: Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous chromosome pairing at meiosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in karyogamy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in localization	IEA Inferred from Electronic Annotation more info
involved_in meiotic telomere clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic telomere clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle pole body duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere tethering at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in half bridge of spindle pole body	IDA Inferred from Direct Assay more info	PubMed
part_of meiotic nuclear membrane microtubule tethering complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	HDA more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole body	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mps3p

NP_012515.4

Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)