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    CDS1 phosphatidate cytidylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852317, updated on 11-Apr-2024

    Summary

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    Gene symbol
    CDS1
    Gene description
    phosphatidate cytidylyltransferase
    Primary source
    SGD:S000000233
    Locus tag
    YBR029C
    See related
    AllianceGenome:SGD:S000000233
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDG1
    Summary
    Enables phosphatidate cytidylyltransferase activity. Involved in CDP-diacylglycerol biosynthetic process; phosphatidylinositol metabolic process; and phosphatidylserine metabolic process. Located in Golgi to plasma membrane transport vesicle and endoplasmic reticulum. Used to study cancer. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CDS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (296369..297742, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative protein kinase YPK3 Neighboring gene protein-lysine N-methyltransferase Neighboring gene ribosomal 60S subunit protein L4A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. Shen H, et al. J Biol Chem, 1996 Jan 12. PMID 8557688
    2. Saccharomyces cerevisiae mutant with a partial defect in the synthesis of CDP-diacylglycerol and altered regulation of phospholipid biosynthesis. Klig LS, et al. J Bacteriol, 1988 Apr. PMID 2832385, Free PMC Article
    3. Purification and characterization of CDP-diacylglycerol synthase from Saccharomyces cerevisiae. Kelley MJ, et al. J Biol Chem, 1987 Oct 25. PMID 2822695
    4. Enzymes of phosphoinositide synthesis in secretory vesicles destined for the plasma membrane in Saccharomyces cerevisiae. Kinney AJ, et al. J Bacteriol, 1990 Jul. PMID 2163397, Free PMC Article
    5. Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA. Weeks R, et al. DNA Cell Biol, 1997 Mar. PMID 9115637

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CDP-diacylglycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylserine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi to plasma membrane transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidate cytidylyltransferase
    NP_009585.1
    • Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      296369..297742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178377.1 → NP_009585.1  TPA: phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ30, P38221
      UniProtKB/TrEMBL
      A0A6A5Q482, A6ZKX4, B3LNB5, B5VDZ7, C7GM24, C8Z423, G2W935, N1P886
      Conserved Domains (1) summary
      cl21502
      Location:96 → 420
      CTP_transf_1; Cytidylyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38221.1

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