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    LAM1 Lam1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856560, updated on 11-Apr-2024

    Summary

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    Gene symbol
    LAM1
    Gene description
    Lam1p
    Primary source
    SGD:S000001198
    Locus tag
    YHR155W
    See related
    AllianceGenome:SGD:S000001198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YSP1
    Summary
    Predicted to enable sterol transporter activity. Involved in intracellular sterol transport. Located in cortical endoplasmic reticulum and mitochondrion. Orthologous to human CCNY (cyclin Y) and CCNYL1 (cyclin Y like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (407103..410789)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Spo16p Neighboring gene Rtt107p Neighboring gene ncRNA Neighboring gene U5 snRNP complex subunit LIN1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. Pozniakovsky AI, et al. J Cell Biol, 2005 Jan 17. PMID 15657396, Free PMC Article
    2. Hydroquinone exposure accumulates neutral lipid by the activation of CDP-DAG pathway in Saccharomyces cerevisiae. Raj A, et al. Toxicol Res (Camb), 2021 Mar. PMID 33884185, Free PMC Article
    3. LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles. Sokolov SS, et al. Front Microbiol, 2020. PMID 32047490, Free PMC Article
    4. Effects of Sterols on the Interaction of SDS, Benzalkonium Chloride, and A Novel Compound, Kor105, with Membranes. Jiménez-Munguía I, et al. Biomolecules, 2019 Oct 18. PMID 31635312, Free PMC Article
    5. A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport. Gatta AT, et al. Elife, 2015 May 22. PMID 26001273, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in intracellular sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lam1p
    NP_012025.1
    • Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      407103..410789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179286.1 → NP_012025.1  TPA: Lam1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012025.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLA4, P38851
      UniProtKB/TrEMBL
      A0A8H4C238, G2WFM8, N1P184
      Conserved Domains (2) summary
      cd07609
      Location:27 → 246
      BAR_SIP3_fungi; The Bin/Amphiphysin/Rvs (BAR) domain of fungal Snf1p-interacting protein 3
      cd13280
      Location:312 → 425
      PH_SIP3; Snf1p-interacting protein 3 Pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38851.1

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