NOS2 nitric oxide synthase 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: NOS2provided by VGNC
Official Full Name: nitric oxide synthase 2provided by VGNC
Primary source: VGNC:VGNC:43895
See related: Ensembl:ENSCAFG00845014798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: INOS; NOS2A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (42989630..43028666, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (41328978..41365802, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (42142975..42179774, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (41770831..41807631, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (42065650..42102448, complement)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis.
Title: Association between intestinal lymphangiectasia and expression of inducible nitric oxide synthase in dogs with lymphoplasmacytic enteritis.
Increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.
Title: Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade.
demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA
Title: Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.
IL-17A gene transcription level was positively correlated with mRNA expression for iNOS and IFN-gamma
Title: Impairment of Interleukin-17A Expression in Canine Visceral Leishmaniosis is Correlated with Reduced Interferon-γ and Inducible Nitric Oxide Synthase Expression.
Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression.
Title: Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
A positive correlation was found between the number of iNOS cells in lymph nodes and interferon-gamma levels, and there was a negative correlation between parasites and iNOS cell densities both in lymph nodes and spleen.
Title: Expression of inducible nitric oxide synthase in macrophages inversely correlates with parasitism of lymphoid tissues in dogs with visceral leishmaniasis.
results showed that the median expression of iNOS was higher in symptomatic dogs and oligosymptomatic dogs compared to non-infected dogs
Title: Qualitative and quantitative immunohistochemical evaluation of iNOS expression in the spleen of dogs naturally infected with Leishmania chagasi.
Chronic non-ischaemic heart failure results in atrial oxidative stress and electrophysiologic abnormalities by depletion of tetrahydrobiopterin and uncoupling of NOS2.
Title: Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology.
treatment with avocado/soybean unsaponifiables can reduce the development of early osteoarthritic cartilage and subchondral bone lesions. This effect appears to be mediated through the inhibition of inducible nitric oxide synthase and MMP-13
Title: Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Inflammatory cytokines and NO form INOS may be involved in intraneural inflammatory changes arising from mechanical compression
Title: Localization and changes of intraneural inflammatory cytokines and inducible-nitric oxide induced by mechanical compression.

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General gene information

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Markers

NOS2A_3339 (e-PCR)
- UniSTS:462373

GDB:437694 (e-PCR)
- UniSTS:157251

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables FMN binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in nitric oxide biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nitric oxide synthase, inducible

Names: NOS type II; inducible NO synthase; inducible NOS; inducible nitric oxide synthase; nitric oxide synthase 2A (inducible, hepatocytes); peptidyl-cysteine S-nitrosylase NOS2

NP_001300777.1

EC 1.14.13.39

XP_038530887.1

EC 1.14.13.39

XP_038530888.1

EC 1.14.13.39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313848.2 → NP_001300777.1 nitric oxide synthase, inducible

Status: VALIDATED

Source sequence(s)

JAAUVH010000313

UniProtKB/TrEMBL

A0A8C0RKD0, A0A8C0T683, A0A8I3NVW8

Related

ENSCAFP00845020859.1, ENSCAFT00845026468.1

Conserved Domains (3) summary

cd00795
Location:84 → 496

NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...

pfam00258
Location:541 → 672

Flavodoxin_1

cl06868
Location:736 → 1132

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

42989630..43028666 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038674959.1 → XP_038530887.1 nitric oxide synthase, inducible isoform X1

UniProtKB/TrEMBL

A0A8C0RKD0, A0A8C0T683, A0A8I3NVW8

Related

ENSCAFP00845020957.1, ENSCAFT00845026593.1

Conserved Domains (3) summary

cd00795
Location:84 → 496

NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...

pfam00258
Location:541 → 672

Flavodoxin_1

cl06868
Location:736 → 1132

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_038674960.1 → XP_038530888.1 nitric oxide synthase, inducible isoform X2

UniProtKB/TrEMBL

A0A8C0RKD9, A0A8C0T6A0, A0A8I3NZL3

Related

ENSCAFP00845021024.1, ENSCAFT00845026680.1

Conserved Domains (3) summary

cd00795
Location:83 → 495

NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...

pfam00258
Location:540 → 671

Flavodoxin_1

cl06868
Location:735 → 1131

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049269.1 Alternate UMICH_Zoey_3.1

Range

41770831..41807631 complement

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Alternate UNSW_CanFamBas_1.0

Genomic

NC_049750.1 Alternate UNSW_CanFamBas_1.0

Range

42065650..42102448 complement

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Alternate UU_Cfam_GSD_1.0

Genomic

NC_049230.1 Alternate UU_Cfam_GSD_1.0

Range

42142975..42179774 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

41328978..41365802 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001003186.1: Suppressed sequence

Description

NM_001003186.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.