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    Fam178b family with sequence similarity 178, member B [ Mus musculus (house mouse) ]

    Gene ID: 381337, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam178bprovided by MGI
    Official Full Name
    family with sequence similarity 178, member Bprovided by MGI
    Primary source
    MGI:MGI:3026913
    See related
    Ensembl:ENSMUSG00000046337 AllianceGenome:MGI:3026913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm990; 1700024G10Rik
    Summary
    Orthologous to human FAM178B (family with sequence similarity 178 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 99.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 B; 1 15.33 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36601779..36722271, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36562696..36683190, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 23 Neighboring gene STARR-positive B cell enhancer ABC_E320 Neighboring gene ankyrin repeat domain 39 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C Neighboring gene STARR-seq mESC enhancer starr_00646 Neighboring gene STARR-positive B cell enhancer ABC_E1539 Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene ARP1 actin-related protein 1B, centractin beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC60970, MGC141033

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM178B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126046.2 → NP_001119518.1  protein FAM178B isoform A

      Status: VALIDATED

      Source sequence(s)
      AC084389, AC084391
      Consensus CDS
      CCDS48241.1
      UniProtKB/Swiss-Prot
      Q24JP3, Q3URT9, Q80VJ7, Q9DA00
      UniProtKB/TrEMBL
      E9PXB2
      Related
      ENSMUSP00000132846.2, ENSMUST00000170295.8
      Conserved Domains (1) summary
      pfam14816
      Location:76 → 382
      FAM178; Family of unknown function, FAM178

    2. NM_001372416.1 → NP_001359345.1  protein FAM178B isoform D

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D) represents the longest transcript and encodes the longest isoform (D).
      Source sequence(s)
      AC084389, AC084391
      Conserved Domains (1) summary
      pfam14816
      Location:73 → 480
      FAM178; Family of unknown function, FAM178

    3. NM_001372417.1 → NP_001359346.1  protein FAM178B isoform E

      Status: VALIDATED

      Source sequence(s)
      AC084389, AC084391
      UniProtKB/Swiss-Prot
      Q24JP3, Q3URT9, Q80VJ7, Q9DA00
      Conserved Domains (1) summary
      pfam14816
      Location:73 → 426
      FAM178; Family of unknown function, FAM178

    4. NM_027957.2 → NP_082233.1  protein FAM178B isoform B

      See identical proteins and their annotated locations for NP_082233.1

      Status: VALIDATED

      Source sequence(s)
      AC084391
      UniProtKB/Swiss-Prot
      Q24JP3
      Related
      ENSMUST00000193763.6

    5. NM_201365.3 → NP_958753.2  protein FAM178B isoform C

      Status: VALIDATED

      Source sequence(s)
      AC084389
      Consensus CDS
      CCDS14885.2
      UniProtKB/TrEMBL
      E9PUL8
      Related
      ENSMUSP00000124023.2, ENSMUST00000114981.3
      Conserved Domains (1) summary
      pfam14816
      Location:76 → 365
      FAM178; Family of unknown function, FAM178

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      36601779..36722271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321446.2 → XP_017176935.1  protein FAM178B isoform X3

      UniProtKB/Swiss-Prot
      Q24JP3, Q3URT9, Q80VJ7, Q9DA00
      Conserved Domains (1) summary
      pfam14816
      Location:73 → 439
      FAM178; Family of unknown function, FAM178

    2. XM_006496116.3 → XP_006496179.1  protein FAM178B isoform X2

      See identical proteins and their annotated locations for XP_006496179.1

      UniProtKB/Swiss-Prot
      Q24JP3, Q3URT9, Q80VJ7, Q9DA00
      Conserved Domains (1) summary
      pfam14816
      Location:73 → 442
      FAM178; Family of unknown function, FAM178

    3. XM_017321439.2 → XP_017176928.1  protein FAM178B isoform X1

      Conserved Domains (1) summary
      pfam14816
      Location:73 → 480
      FAM178; Family of unknown function, FAM178

    4. XM_030255205.1 → XP_030111065.1  protein FAM178B isoform X6

      Conserved Domains (1) summary
      pfam14816
      Location:1 → 176
      FAM178; Family of unknown function, FAM178

    5. XM_036166197.1 → XP_036022090.1  protein FAM178B isoform X6

      Conserved Domains (1) summary
      pfam14816
      Location:1 → 176
      FAM178; Family of unknown function, FAM178

    6. XM_036166198.1 → XP_036022091.1  protein FAM178B isoform X7

      Conserved Domains (1) summary
      pfam14816
      Location:1 → 230
      FAM178; Family of unknown function, FAM178

    7. XM_017321452.3 → XP_017176941.1  protein FAM178B isoform X8

      Conserved Domains (1) summary
      pfam14816
      Location:1 → 91
      FAM178; Family of unknown function, FAM178

    8. XM_011238555.4 → XP_011236857.1  protein FAM178B isoform X9

      See identical proteins and their annotated locations for XP_011236857.1

      UniProtKB/Swiss-Prot
      Q24JP3

    9. XM_006496122.5 → XP_006496185.1  protein FAM178B isoform X9

      See identical proteins and their annotated locations for XP_006496185.1

      UniProtKB/Swiss-Prot
      Q24JP3
      Related
      ENSMUST00000193548.6

    10. XM_017321449.2 → XP_017176938.1  protein FAM178B isoform X4

      Conserved Domains (1) summary
      pfam14816
      Location:73 → 462
      FAM178; Family of unknown function, FAM178

    11. XM_017321451.1 → XP_017176940.1  protein FAM178B isoform X5

      Conserved Domains (1) summary
      pfam14816
      Location:73 → 368
      FAM178; Family of unknown function, FAM178
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24JP3.2 GenPept UniProtKB/Swiss-Prot:Q24JP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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