Ptpn1 protein tyrosine phosphatase, non-receptor type 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn1provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 1provided by MGI
Primary source: MGI:MGI:97805
See related: Ensembl:ENSMUSG00000027540 AllianceGenome:MGI:97805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PTP1B; PTP-1B; PTP-HA2
Summary: Predicted to enable several functions, including protein phosphatase 2A binding activity; signaling receptor binding activity; and zinc ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; negative regulation of signal transduction; and peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Acts upstream of or within insulin receptor signaling pathway and protein dephosphorylation. Located in early endosome and sorting endosome. Is expressed in central nervous system; midbrain; and superior colliculus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PTPN1 (protein tyrosine phosphatase non-receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 41.9), ovary adult (RPKM 30.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (167772670..167821305)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167930750..167979385)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity.
Title: Overexpression of forebrain PTP1B leads to synaptic and cognitive impairments in obesity.
PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin.
Title: PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy.
Title: Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy.
miR-124-3p regulates the involvement of Ptpn1 in testicular development and spermatogenesis in mouse.
Title: miR-124-3p regulates the involvement of Ptpn1 in testicular development and spermatogenesis in mouse.
Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte.
Title: Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte.
PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Title: PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
PTP1B Inhibitor Claramine Rescues Diabetes-Induced Spatial Learning and Memory Impairment in Mice.
Title: PTP1B Inhibitor Claramine Rescues Diabetes-Induced Spatial Learning and Memory Impairment in Mice.
Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.
Title: Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.
Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury.
Title: Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury.
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications.
Title: The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications.

Submit: New GeneRIF Correction See all GeneRIFs (181)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI256593 (e-PCR)
- UniSTS:207449

NoName (e-PCR)
- UniSTS:234610

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of PERK-mediated unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of PERK-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in platelet-derived growth factor receptor-beta signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed
is_active_in endosome lumen	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial crista	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in sorting endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 1

Names: protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; protein-tyrosine phosphatase HA2

NP_035331.3

EC 3.1.3.48

XP_006499044.1

EC 3.1.3.48

XP_036015579.1

EC 3.1.3.48

XP_036015580.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011201.3 → NP_035331.3 tyrosine-protein phosphatase non-receptor type 1

See identical proteins and their annotated locations for NP_035331.3

Status: VALIDATED

Source sequence(s)

AL928998

Consensus CDS

CCDS17107.1

UniProtKB/Swiss-Prot

P35821, Q60840, Q62131, Q64498, Q99JS1

UniProtKB/TrEMBL

Q3TZW9, Q3UCZ5

Related

ENSMUSP00000029053.8, ENSMUST00000029053.8

Conserved Domains (2) summary

smart00194
Location:3 → 276

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:43 → 276

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

167772670..167821305

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159687.1 → XP_036015580.1 tyrosine-protein phosphatase non-receptor type 1 isoform X3

UniProtKB/TrEMBL

Q3T9Y9

Conserved Domains (1) summary

cl28904
Location:1 → 217

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_036159686.1 → XP_036015579.1 tyrosine-protein phosphatase non-receptor type 1 isoform X2

UniProtKB/TrEMBL

Q3TB93

Conserved Domains (1) summary

cl28904
Location:16 → 290

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006498981.5 → XP_006499044.1 tyrosine-protein phosphatase non-receptor type 1 isoform X1

UniProtKB/TrEMBL

Q3UCZ5

Related

ENSMUST00000126839.8

Conserved Domains (1) summary

cl28904
Location:1 → 219

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily