Fas Fas cell surface death receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fasprovided by MGI
Official Full Name: Fas cell surface death receptorprovided by MGI
Primary source: MGI:MGI:95484
See related: Ensembl:ENSMUSG00000024778 AllianceGenome:MGI:95484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lpr; APO1; APT1; CD95; TNFR6; Tnfrsf6
Summary: Enables identical protein binding activity. Involved in positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway; hematopoietic or lymphoid organ development; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; systemic lupus erythematosus; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 4.7), bladder adult (RPKM 3.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 29.48 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34267926..34305175)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34290647..34327775)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth.
Title: Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth.
CRISPR/Cas9-mediated abrogation of CD95L/CD95 signaling-induced glioma cell growth and immunosuppression increases survival in murine glioma models.
Title: CRISPR/Cas9-mediated abrogation of CD95L/CD95 signaling-induced glioma cell growth and immunosuppression increases survival in murine glioma models.
E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
Title: E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.
Title: Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.
Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.
Title: Fas/FasL Contributes to HSV-1 Brain Infection and Neuroinflammation.
Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice.
Title: Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice.
Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens.
Title: Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens.
Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.
Title: Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells.
Title: Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells.
Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis.
Title: Loss of Fas signaling in fibroblasts impairs homeostatic fibrosis resolution and promotes persistent pulmonary fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (361)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (7) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M83649 (e-PCR)
- UniSTS:163613

Tnfrsf6 (e-PCR), detects polymorphism
- UniSTS:143071

Tnfrsf6 (e-PCR), detects polymorphism
- UniSTS:143072

AI196731 (e-PCR)
- UniSTS:181226

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Fas signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation-induced cell death of T cells	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation-induced cell death of T cells	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within activation-induced cell death of T cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hyperoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lithium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendrite regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflammatory cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in motor neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necroptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within necroptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of B cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Schwann cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to glucocorticoid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spleen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CD95 death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CD95 death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
part_of CD95 death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 6

Names: FASLG receptor; Fas (TNF receptor superfamily member 6); Fas (TNF receptor superfamily member); Fas antigen; apo-1 antigen; apoptosis-mediating surface antigen FAS; lymphoproliferation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146708.1 → NP_001140180.1 tumor necrosis factor receptor superfamily member 6 isoform 2 precursor

See identical proteins and their annotated locations for NP_001140180.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 3' end, compared to variant 1. These differences produce a unique 3' UTR and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK086933, BY348234

Consensus CDS

CCDS50420.1

UniProtKB/TrEMBL

D3Z6E5, Q8C350

Related

ENSMUSP00000108091.3, ENSMUST00000112472.4

Conserved Domains (1) summary

cl22855
Location:35 → 61

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_007987.2 → NP_032013.2 tumor necrosis factor receptor superfamily member 6 isoform 1 precursor

See identical proteins and their annotated locations for NP_032013.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC061160, BY348234

Consensus CDS

CCDS29758.1

UniProtKB/Swiss-Prot

P25446, Q6GT31, Q9DCQ1

UniProtKB/TrEMBL

A0A494BBP5

Related

ENSMUSP00000025691.6, ENSMUST00000025691.13

Conserved Domains (2) summary

cd08316
Location:218 → 309

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd10579
Location:35 → 163

TNFRSF6; Tumor necrosis factor receptor superfamily member 6 (TNFRSF6), also known as fas cell surface death receptor (Fas)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

34267926..34305175

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250746.2 → XP_030106606.1 tumor necrosis factor receptor superfamily member 6 isoform X1

UniProtKB/TrEMBL

A1Y9B2

Conserved Domains (3) summary

cd08316
Location:193 → 284

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:56 → 98

TNFRSF; CRD2 [structural motif]

cl22855
Location:38 → 138

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_030250747.2 → XP_030106607.1 tumor necrosis factor receptor superfamily member 6 isoform X1

UniProtKB/TrEMBL

A1Y9B2

Conserved Domains (3) summary

cd08316
Location:193 → 284

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:56 → 98

TNFRSF; CRD2 [structural motif]

cl22855
Location:38 → 138

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_030250749.2 → XP_030106609.1 tumor necrosis factor receptor superfamily member 6 isoform X1

UniProtKB/TrEMBL

A1Y9B2

Conserved Domains (3) summary

cd08316
Location:193 → 284

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:56 → 98

TNFRSF; CRD2 [structural motif]

cl22855
Location:38 → 138

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_030250748.2 → XP_030106608.1 tumor necrosis factor receptor superfamily member 6 isoform X1

UniProtKB/TrEMBL

A1Y9B2

Conserved Domains (3) summary

cd08316
Location:193 → 284

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:56 → 98

TNFRSF; CRD2 [structural motif]

cl22855
Location:38 → 138

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_030250751.2 → XP_030106611.1 tumor necrosis factor receptor superfamily member 6 isoform X2

Conserved Domains (3) summary

cd08316
Location:148 → 239

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:11 → 53

TNFRSF; CRD2 [structural motif]

cl22855
Location:1 → 93

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_036161430.1 → XP_036017323.1 tumor necrosis factor receptor superfamily member 6 isoform X2

Conserved Domains (3) summary

cd08316
Location:148 → 239

Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6

cd00185
Location:11 → 53

TNFRSF; CRD2 [structural motif]

cl22855
Location:1 → 93

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)