Cd82 CD82 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd82provided by MGI
Official Full Name: CD82 antigenprovided by MGI
Primary source: MGI:MGI:104651
See related: Ensembl:ENSMUSG00000027215 AllianceGenome:MGI:104651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C33; IA4; Kai1; Tspan27
Summary: Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including choroid plexus; foregut; limb segment; meninges; and olfactory epithelium. Orthologous to human CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 142.7), duodenum adult (RPKM 91.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 51.62 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (93249447..93293295, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (93419102..93462950, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
Title: Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
Tetraspanin CD82 regulates S1PR1-mediated hematopoietic stem and progenitor cell mobilization.
Title: Tetraspanin CD82 regulates S1PR(1)-mediated hematopoietic stem and progenitor cell mobilization.
KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.
Title: KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.
Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.
Title: Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function.
CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
Title: CD82-TRPM7-Numb signaling mediates age-related cognitive impairment.
study demonstrates that CD82 is a specific regulator of TLR9 signaling, which may be critical in cancer immunotherapy approaches and coordinating the innate immune response to pathogens.
Title: CD82 controls CpG-dependent TLR9 signaling.
these data demonstrate that CD82 organizes the proper assembly of Dectin-1 signaling machinery in response to Candida albicans
Title: Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans.
Data provide evidence that CD82 is an important regulator of HSPC bone marrow maintenance, homing, and engraftment.
Title: The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells.
Loss of CD82 resulted in defects in osteoclast, osteoblast, and adipocyte lineages.
Title: Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.
CD82-RUNX1-Rab5/22 axis may be a previously unrecognized virulence mechanism of Mycobacterium tuberculosis pathogenesis.
Title: CD82 hypomethylation is essential for tuberculosis pathogenesis via regulation of RUNX1-Rab5/22.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127894 (e-PCR)
- UniSTS:211204

RH124534 (e-PCR)
- UniSTS:161356

RH125449 (e-PCR)
- UniSTS:162268

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD82 antigen

Names: C33 antigen; inducible membrane protein R2; kangai 1 (suppression of tumorigenicity 6, prostate); metastasis suppressor Kangai-1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136055.2 → NP_001129527.1 CD82 antigen

See identical proteins and their annotated locations for NP_001129527.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AK135381, AL732483, BM215013

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Related

ENSMUSP00000112158.3, ENSMUST00000116457.9

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001271430.1 → NP_001258359.1 CD82 antigen

See identical proteins and their annotated locations for NP_001258359.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AK135381, AK160907, AL732483, BM215013

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Related

ENSMUSP00000097287.2, ENSMUST00000099696.8

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001271431.1 → NP_001258360.1 CD82 antigen

See identical proteins and their annotated locations for NP_001258360.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AL732483

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001271432.1 → NP_001258361.1 CD82 antigen

See identical proteins and their annotated locations for NP_001258361.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AL732483

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001271461.1 → NP_001258390.1 CD82 antigen

See identical proteins and their annotated locations for NP_001258390.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AL732483

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_001271462.1 → NP_001258391.1 CD82 antigen

See identical proteins and their annotated locations for NP_001258391.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AL732483

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Related

ENSMUSP00000106888.2, ENSMUST00000111257.8

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
NM_007656.5 → NP_031682.1 CD82 antigen

See identical proteins and their annotated locations for NP_031682.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.

Source sequence(s)

AL732483

Consensus CDS

CCDS16454.1

UniProtKB/Swiss-Prot

P40237

UniProtKB/TrEMBL

Q3UII2

Related

ENSMUSP00000028644.5, ENSMUST00000028644.11

Conserved Domains (1) summary

cd03160
Location:106 → 228

CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...