Vsnl1 visinin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vsnl1provided by MGI
Official Full Name: visinin-like 1provided by MGI
Primary source: MGI:MGI:1349453
See related: Ensembl:ENSMUSG00000054459 AllianceGenome:MGI:1349453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VILIP; Vnsl1
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within negative regulation of insulin secretion; positive regulation of exocytosis; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; brain; great vessel of heart; heart; and sensory organ. Orthologous to human VSNL1 (visinin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 134.2), cerebellum adult (RPKM 127.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 5.58 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (11375258..11486579, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (11325257..11436578, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results demonstrated that...Helios has a specific and important role for a correct function of hippocampal calbindin-positive CA1 pyramidal neurons regulating spinogenesis...and that Visinin-like protein 1 (VSNL1) could play an important role in such processes
Title: Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.
Findings indicate that VILIP-1 is involved in epithelial-mesenchymal transition (EMT) of squamous cell carcinoma (SCC) cells by regulating the transcription factor Snail1 in a cAMP-dependent manner.
Title: The putative tumor suppressor VILIP-1 counteracts epidermal growth factor-induced epidermal-mesenchymal transition in squamous carcinoma cells.
VSNL1 expresses exclusively in atrial cardiomyocytes during embryogenesis.
Title: The expression of Visinin-like 1 during mouse embryonic development.
VILIP-1 overexpression decreases the susceptibility to skin carcinogenesis in experimental mouse cancer models, thus supporting its role as a tumor suppressor gene
Title: VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development.
Data show that VILIP-1 led to reduced migration of aggressive SCC cells depending on cAMP levels.
Title: Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma.
Vsnl1 marks ureteric bud tips in embryonic kidneys, and its mosaic pattern demonstrates a heterogeneity of cell types that may be critical for normal ureteric branching.
Title: The GDNF target Vsnl1 marks the ureteric tip.
VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors
Title: Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1.
Decreased or absent VILIP-1 expression in SCC cell subpopulations may lead to a more advanced malignant phenotype characterized by changes in adhesive ability and increased cell motility, suggestive of a tumor suppressor function
Title: Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80046 (e-PCR)
- UniSTS:83724

NoName (e-PCR)
- UniSTS:224321

D6Arb7 (e-PCR), detects polymorphism
- UniSTS:227972

AW742598 (e-PCR)
- UniSTS:208774

D6Rat38 (e-PCR), detects polymorphism
- UniSTS:228066

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: visinin-like protein 1

Names: NVL-1; NVP-1; neural visinin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378929.1 → NP_001365858.1 visinin-like protein 1

Status: VALIDATED

Source sequence(s)

AC139207

UniProtKB/Swiss-Prot

P62761

UniProtKB/TrEMBL

Q3TVC0, Q4W4C9

Related

ENSMUSP00000152711.2, ENSMUST00000220506.2

Conserved Domains (1) summary

COG5126
Location:15 → 181

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_012038.5 → NP_036168.1 visinin-like protein 1

See identical proteins and their annotated locations for NP_036168.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC139207

Consensus CDS

CCDS25816.1

UniProtKB/Swiss-Prot

P62761

UniProtKB/TrEMBL

Q3TVC0, Q4W4C9

Related

ENSMUSP00000072145.6, ENSMUST00000072299.7

Conserved Domains (1) summary

COG5126
Location:15 → 181

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]