Il12rb2 interleukin 12 receptor, beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il12rb2provided by MGI
Official Full Name: interleukin 12 receptor, beta 2provided by MGI
Primary source: MGI:MGI:1270861
See related: Ensembl:ENSMUSG00000018341 AllianceGenome:MGI:1270861
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ifnm; IL-12RB2; A930027I18Rik
Summary: Enables protein kinase binding activity. Acts upstream of or within peptidyl-tyrosine phosphorylation; response to cytokine; and response to lipopolysaccharide. Located in external side of plasma membrane. Is expressed in several structures, including brain ventricular layer; genitourinary system; incisor; olfactory epithelium; and submandibular gland. Orthologous to human IL12RB2 (interleukin 12 receptor subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 1.8), cerebellum adult (RPKM 1.2) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 30.81 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (67263914..67353277, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (67285986..67376293, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation.
Title: IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation.
Autocrine TGF-beta1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rbeta2 Downregulation.
Title: Autocrine TGF-β1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rβ2 Downregulation.
Morphological and Functional Characterization of IL-12Rbeta2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.
Title: Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation.
These results provide a new pathway of Th1 response regulation where IL-12 secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.
Title: Dendritic Cells Induce a Subpopulation of IL-12Rβ2-Expressing Treg that Specifically Consumes IL-12 to Control Th1 Responses.
in neonatal mice, IL-12 uses IL-12Rbeta2 to counter IL-13Ralpha1 expression in addition to promoting Th1 differentiation
Title: Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.
survival of secondary LVS challenge was not strictly dependent on IL-12Rbeta2
Title: IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.
Data indicate that delayed induction of the IL-12Rbeta2 receptor component after STAT1 activation helped ensure that Treg cells do not readily complete STAT4-dependent Th1 cell development and lose their ability to suppress effector T cell proliferation.
Title: T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
Title: The composition and signaling of the IL-35 receptor are unconventional.
IL-12R-beta2 signaling is essential for Plasmodium berghei ANKA-induced experimental cerebral malaria development
Title: IL-12Rβ2 is essential for the development of experimental cerebral malaria.
Data show that T(H)1 differentiation was impaired in Il2(-/-) T cells but was restored by IL-12Rbeta2 expression.
Title: Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U64199 (e-PCR)
- UniSTS:163388

D6Dcr13 (e-PCR), detects polymorphism
- UniSTS:507743

D6Dcr14 (e-PCR), detects polymorphism
- UniSTS:507744

AW493563 (e-PCR)
- UniSTS:179387

Z72360 (e-PCR)
- UniSTS:64232

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-12 receptor subunit beta-2

Names: IL-12 receptor subunit beta-2; IL-12R subunit beta-2; interferon response to microorganisms

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311141.1 → NP_001298070.1 interleukin-12 receptor subunit beta-2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and therefore, differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC130822, BC137745

Consensus CDS

CCDS80543.1

UniProtKB/TrEMBL

D3Z6H5

Related

ENSMUSP00000113267.2, ENSMUST00000117441.8

Conserved Domains (2) summary

cd00063
Location:104 → 191

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:202 → 289

fn3; Fibronectin type III domain
NM_008354.4 → NP_032380.1 interleukin-12 receptor subunit beta-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_032380.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC130822

Consensus CDS

CCDS20220.1

UniProtKB/Swiss-Prot

B9EHD9, P97378

Related

ENSMUSP00000010605.4, ENSMUST00000018485.4

Conserved Domains (3) summary

cd00063
Location:240 → 332

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:438 → 523

fn3; Fibronectin type III domain

pfam06328
Location:28 → 120

Lep_receptor_Ig; Ig-like C2-type domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

67263914..67353277 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505617.5 → XP_006505680.1 interleukin-12 receptor subunit beta-2 isoform X1

See identical proteins and their annotated locations for XP_006505680.1

UniProtKB/Swiss-Prot

B9EHD9, P97378

Conserved Domains (3) summary

cd00063
Location:240 → 332

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:438 → 523

fn3; Fibronectin type III domain

pfam06328
Location:28 → 120

Lep_receptor_Ig; Ig-like C2-type domain