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    Vezt vezatin, adherens junctions transmembrane protein [ Mus musculus (house mouse) ]

    Gene ID: 215008, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Veztprovided by MGI
    Official Full Name
    vezatin, adherens junctions transmembrane proteinprovided by MGI
    Primary source
    MGI:MGI:2143698
    See related
    Ensembl:ENSMUSG00000036099 AllianceGenome:MGI:2143698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630071D13Rik
    Summary
    This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.8), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vezt in Genome Data Viewer
    Location:
    10; 10 C2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93797384..93871661, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93961522..94035799, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene methionine aminopeptidase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene STARR-positive B cell enhancer ABC_E1811 Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene B-cell CLL/lymphoma 9-like pseudogene Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene predicted gene, 26122

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation. Danglot L, et al. J Neurosci, 2012 Jun 27. PMID 22745500, Free PMC Article
    2. Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons. Sanda M, et al. Neurosci Res, 2010 Jun. PMID 20188128
    3. Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells. Bahloul A, et al. EMBO Mol Med, 2009 May. PMID 20049712, Free PMC Article
    4. Vezatin, a ubiquitous protein of adherens cell-cell junctions, is exclusively expressed in germ cells in mouse testis. Hyenne V, et al. Reproduction, 2007 Mar. PMID 17379651
    5. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity. Wang Y, et al. Cell Death Dis, 2021 Oct 12. PMID 34642320, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
      Title: Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity.
    2. These results suggest a role of Vezatin in dendritic spine morphogenesis and functional synaptic maturation.
      Title: Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.
    3. present study suggests that vezatin may regulate dendritic formation as a downstream effector of ARF6.
      Title: Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.
    4. vezatin associates with actin filaments at cell-cell junctions.
      Title: Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.
    5. These in vitro observations reinforce the idea that homozygous vezatin-null mutants die at the time of implantation because of a defect in intercellular adhesion.
      Title: Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation.
    6. Required for morphogenesis of the preimplantation mouse embryo.
      Title: Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 6330418D12

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synapse maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of stereocilia ankle link complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vezatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304572.1 → NP_001291501.1  vezatin isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122901, AK031192, AK042209, AW124866, BC056428, BQ555053
      Consensus CDS
      CCDS78886.1
      UniProtKB/Swiss-Prot
      Q3ZK22
      Related
      ENSMUSP00000113983.2, ENSMUST00000118077.8
      Conserved Domains (1) summary
      pfam12632
      Location:150 → 438
      Vezatin; Mysoin-binding motif of peroxisomes

    2. NM_001304575.1 → NP_001291504.1  vezatin isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the central coding region, compared to variant 1. It encodes isoform 3, which is longer and has a distinct internal segment, compared to isoform 1.
      Source sequence(s)
      AC122901, AK031192, AK031848, AK036017, AK042209, AW124866, BC056428
      Consensus CDS
      CCDS78887.1
      UniProtKB/TrEMBL
      D3Z4E6
      Related
      ENSMUSP00000113715.2, ENSMUST00000119818.8
      Conserved Domains (2) summary
      pfam10243
      Location:463 → 772
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12632
      Location:150 → 442
      Vezatin; Mysoin-binding motif of peroxisomes

    3. NM_001304720.1 → NP_001291649.1  vezatin isoform 4

      See identical proteins and their annotated locations for NP_001291649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' terminal exon compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122901, AK031192, AK042209, AK042540, AW124866, BQ555053, CF730355
      Consensus CDS
      CCDS83750.1
      UniProtKB/Swiss-Prot
      Q3ZK22
      Related
      ENSMUSP00000113321.2, ENSMUST00000118205.8
      Conserved Domains (1) summary
      pfam12632
      Location:150 → 438
      Vezatin; Mysoin-binding motif of peroxisomes

    4. NM_172538.5 → NP_766126.2  vezatin isoform 1

      See identical proteins and their annotated locations for NP_766126.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC122901, AK031192, AK031848, AK036017, AK042209, AK048068, AW124866, BC056428
      Consensus CDS
      CCDS36038.1
      UniProtKB/Swiss-Prot
      A0M8X3, Q3ZK21, Q3ZK22, Q8BY12, Q8BYB4, Q8BZB5
      Related
      ENSMUSP00000037955.7, ENSMUST00000047711.13
      Conserved Domains (2) summary
      pfam10243
      Location:459 → 768
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12632
      Location:150 → 438
      Vezatin; Mysoin-binding motif of peroxisomes

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93797384..93871661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZK22.2 GenPept UniProtKB/Swiss-Prot:Q3ZK22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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