Crhr1 corticotropin releasing hormone receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crhr1provided by MGI
Official Full Name: corticotropin releasing hormone receptor 1provided by MGI
Primary source: MGI:MGI:88498
See related: Ensembl:ENSMUSG00000018634 AllianceGenome:MGI:88498
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crhr; CRF1R; CRFR1; CRF-R1alpha
Summary: The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates adenylate cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in cerebellum adult (RPKM 7.7), frontal lobe adult (RPKM 4.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 67.77 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (104021289..104066349)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (104130463..104175523)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression.
Title: Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice.
Title: Changes in Corticotropin-Releasing Factor Receptor Type 1, Co-Expression with Tyrosine Hydroxylase and Oxytocin Neurons, and Anxiety-Like Behaviors across the Postpartum Period in Mice.
The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.
Title: The Nucleus Accumbens CRH-CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse.
Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making.
Title: Corticotropin-releasing factor receptor 1 in infralimbic cortex modulates social stress-altered decision-making.
The CRF1 receptor mediates social behavior deficits induced by opiate withdrawal.
Title: The CRF(1) receptor mediates social behavior deficits induced by opiate withdrawal.
Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period.
Title: Alterations in corticotropin-releasing factor receptor type 1 in the preoptic area and hypothalamus in mice during the postpartum period.
Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.
Title: Prenatally traumatized mice reveal hippocampal methylation and expression changes of the stress-related genes Crhr1 and Fkbp5.
Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure.
Title: Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure.
Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST.
Title: Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF(1) receptors in the medial prefrontal cortex and BNST.
Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke.
Title: Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA(2) phosphorylation in experimental ischemic stroke.

Submit: New GeneRIF Correction See all GeneRIFs (126)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (13) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497466

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497467

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497475

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497476

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497477

UniSTS:497478 (e-PCR)
- UniSTS:497478

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497478

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497479

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497480

Crhr1 (e-PCR), detects polymorphism
- UniSTS:497481

GDB:572888 (e-PCR)
- UniSTS:157778

L35593 (e-PCR)
- UniSTS:146611

ODOSTSI (e-PCR)
- UniSTS:146611

NoName (e-PCR)
- UniSTS:484845

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables corticotrophin-releasing factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotrophin-releasing factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables corticotrophin-releasing factor receptor activity	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone binding	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to corticotropin-releasing hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to corticotropin-releasing hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in corticotropin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within general adaptation syndrome, behavioral process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of corticosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: corticotropin-releasing factor receptor 1

Names: CRF 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313928.1 → NP_001300857.1 corticotropin-releasing factor receptor 1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK144430, AK158806, BQ174858, BY278495, CJ143058, CJ155572, FJ668671

UniProtKB/TrEMBL

K9J9G1

Conserved Domains (2) summary

pfam00002
Location:76 → 319

7tm_2; 7 transmembrane receptor (Secretin family)

cl02422
Location:28 → 71

HRM; Hormone receptor domain
NM_001313929.1 → NP_001300858.1 corticotropin-releasing factor receptor 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK144430, AK158806, BC105673, BQ174858, BY278495, CJ143058, CJ155572

UniProtKB/TrEMBL

Q0VGH2

Conserved Domains (2) summary

cd14964
Location:23 → 43

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 175

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_007762.5 → NP_031788.1 corticotropin-releasing factor receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_031788.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK144430, AK158806, BQ174858, CJ143058, CJ155572

Consensus CDS

CCDS25526.1

UniProtKB/Swiss-Prot

P35347

UniProtKB/TrEMBL

Q3ZAT0

Related

ENSMUSP00000091455.5, ENSMUST00000093925.5

Conserved Domains (2) summary

smart00008
Location:40 → 111

HormR; Domain present in hormone receptors

pfam00002
Location:116 → 359

7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

104021289..104066349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156275.1 → XP_036012168.1 corticotropin-releasing factor receptor 1 isoform X2

UniProtKB/TrEMBL

Q0VGH2

Conserved Domains (2) summary

cd14964
Location:23 → 43

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:1 → 175

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036156274.1 → XP_036012167.1 corticotropin-releasing factor receptor 1 isoform X1

Conserved Domains (1) summary

cd15445
Location:75 → 339

7tmB1_CRF-R1; corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors
XM_017314246.1 → XP_017169735.1 corticotropin-releasing factor receptor 1 isoform X1

Conserved Domains (1) summary

cd15445
Location:75 → 339

7tmB1_CRF-R1; corticotropin-releasing factor receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors