U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Il10 interleukin 10 [ Mus musculus (house mouse) ]

    Gene ID: 16153, updated on 16-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Il10provided by MGI
    Official Full Name
    interleukin 10provided by MGI
    Primary source
    MGI:MGI:96537
    See related
    Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CSIF; If2a; Il-10
    Summary
    This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Il10 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130947459..130952707)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131019845..131024970)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 19 Neighboring gene predicted gene, 41952 Neighboring gene STARR-positive B cell enhancer ABC_E9479 Neighboring gene STARR-positive B cell enhancer ABC_E7747 Neighboring gene STARR-positive B cell enhancer ABC_E5793 Neighboring gene MAP kinase-activated protein kinase 2 Neighboring gene STARR-seq mESC enhancer starr_02207 Neighboring gene predicted gene, 25549 Neighboring gene STARR-positive B cell enhancer ABC_E5794 Neighboring gene predicted gene, 51643

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors in Mast Cells. Riquelme-Neira R, et al. Int J Mol Sci, 2023 Jun 8. PMID 37373041, Free PMC Article
    2. Effect of transduced mesenchymal stem cells with IL-10 gene on control of allergic asthma. Hou C, et al. Allergol Immunopathol (Madr), 2023. PMID 36916087
    3. IL-10-providing B cells govern pro-inflammatory activity of macrophages and microglia in CNS autoimmunity. Geladaris A, et al. Acta Neuropathol, 2023 Apr. PMID 36854993, Free PMC Article
    4. Heavy-ion radiation-induced colitis and colorectal carcinogenesis in Il10-/- mice display co-activation of β-catenin and NF-κB signaling. Suman S, et al. PLoS One, 2022. PMID 36584137, Free PMC Article
    5. Deleting interleukin-10 from myeloid cells exacerbates atherosclerosis in Apoe(-/-) mice. Orecchioni M, et al. Cell Mol Life Sci, 2022 Dec 10. PMID 36496494, Free PMC Article

    See all (2236) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
      Title: Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice.
    2. CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.
      Title: CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.
    3. IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.
      Title: IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.
    4. Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy.
      Title: Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy.
    5. IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
      Title: IL-15 Complex-Induced IL-10 Enhances Plasmodium-specific CD4+ T Follicular Helper Differentiation and Antibody Production.
    6. Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice.
      Title: Acute exercise modulates Trim63 and Bmal1 in the skeletal muscle of IL-10 knockout mice.
    7. IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke.
      Title: IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke.
    8. Interleukin-10 gene intervention ameliorates liver fibrosis by enhancing the immune function of natural killer cells in liver tissue.
      Title: Interleukin-10 gene intervention ameliorates liver fibrosis by enhancing the immune function of natural killer cells in liver tissue.
    9. Secreted IgM modulates IL-10 expression in B cells.
      Title: Secreted IgM modulates IL-10 expression in B cells.
    10. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response.
      Title: Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response.
    Submit: New GeneRIF Correction See all GeneRIFs (1127)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (15)  1 citation
    • Endonuclease-mediated (7) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables interleukin-10 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of chronic inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of chronic inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of plasma cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to molecule of bacterial origin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    interleukin-10
    Names
    cytokine synthesis inhibitory factor
    interferon 2a

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010548.2 → NP_034678.1  interleukin-10 precursor

      See identical proteins and their annotated locations for NP_034678.1

      Status: REVIEWED

      Source sequence(s)
      AK152344, AL513351
      Consensus CDS
      CCDS15265.1
      UniProtKB/Swiss-Prot
      P18893, Q0VBJ1
      UniProtKB/TrEMBL
      A0A7R8GUQ3, Q3U879
      Related
      ENSMUSP00000016673.6, ENSMUST00000016673.6
      Conserved Domains (1) summary
      pfam00726
      Location:15 → 174
      IL10; Interleukin 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130947459..130952707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162094.1 → XP_036017987.1  interleukin-10 isoform X1

      UniProtKB/TrEMBL
      Q3U879
      Conserved Domains (1) summary
      cl02501
      Location:15 → 153
      IL10; Interleukin 10
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18893.2 GenPept UniProtKB/Swiss-Prot:P18893

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous