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    NOG2 putative GTPase NOG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855789, updated on 13-Apr-2024

    Summary

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    Gene symbol
    NOG2
    Gene description
    putative GTPase NOG2
    Primary source
    SGD:S000005336
    Locus tag
    YNR053C
    See related
    AllianceGenome:SGD:S000005336
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NUG2
    Summary
    Enables large ribosomal subunit rRNA binding activity. Involved in regulation of ribosomal subunit export from nucleus and ribosomal large subunit export from nucleus. Located in nucleolus and nucleoplasm. Part of preribosome, large subunit precursor. Orthologous to human GNL2 (G protein nucleolar 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    2
    Sequence:
    Chromosome: XIV; NC_001146.8 (721120..723112, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Bre5p Neighboring gene CCR4-NOT core DEDD family RNase subunit POP2 Neighboring gene ncRNA Neighboring gene RNA-binding ATPase activator ESF2 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae. Białkowska A, et al. Acta Biochim Pol, 2002. PMID 12362983
    2. Disruption of ribosome assembly in yeast blocks cotranscriptional pre-rRNA processing and affects the global hierarchy of ribosome biogenesis. Talkish J, et al. RNA, 2016 Jun. PMID 27036125, Free PMC Article
    3. OXPHOS deficiency activates global adaptation pathways to maintain mitochondrial membrane potential. Liu S, et al. EMBO Rep, 2021 Apr 7. PMID 33655635, Free PMC Article
    4. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. Lebreton A, et al. J Biol Chem, 2006 Sep 15. PMID 16861225
    5. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Lebreton A, et al. Nucleic Acids Res, 2008 Sep. PMID 18658244, Free PMC Article

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 and eL43 act in concert to facilitate the release of nascent large ribosomal subunits from the nucleolus.
      Title: Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 and eL43 act in concert to facilitate the release of nascent large ribosomal subunits from the nucleolus.
    2. Nug2 is a regulatory GTPase that monitors pre-60S maturation, with release from its placeholder site linked to recruitment of the nuclear export machinery
      Title: Coupled GTPase and remodelling ATPase activities form a checkpoint for ribosome export.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables large ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of ribosomal subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative GTPase NOG2
    NP_014451.1
    • Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      721120..723112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183230.1 → NP_014451.1  TPA: putative GTPase NOG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1M8, P53742
      UniProtKB/TrEMBL
      A6ZSC7, B3LPJ0, C8ZFT2, G2WLB0
      Conserved Domains (2) summary
      cd01858
      Location:214 → 370
      NGP_1; A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases
      pfam08153
      Location:41 → 171
      NGP1NT; NGP1NT (NUC091) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3JCT_m.1
    6M62_m.1
    6N8J_m.1
    P53742.1

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