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    NKP2 Nkp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851025, updated on 11-Apr-2024

    Summary

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    Gene symbol
    NKP2
    Gene description
    Nkp2p
    Primary source
    SGD:S000004307
    Locus tag
    YLR315W
    See related
    AllianceGenome:SGD:S000004307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in chromosome segregation. Located in kinetochore. Colocalizes with spindle pole body. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (764808..765269)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sph1p Neighboring gene septin CDC3 Neighboring gene Tad3p Neighboring gene telomerase reverse transcriptase Neighboring gene Bud6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore. Tirupataiah S, et al. Mol Biol Rep, 2014 Feb. PMID 24385296
    2. The kinetochore prevents centromere-proximal crossover recombination during meiosis. Vincenten N, et al. Elife, 2015 Dec 14. PMID 26653857, Free PMC Article
    3. Functional dissection of a HECT ubiquitin E3 ligase. Lu JY, et al. Mol Cell Proteomics, 2008 Jan. PMID 17951556, Free PMC Article
    4. The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T. Hinshaw SM, et al. Curr Biol, 2020 Sep 7. PMID 32679099
    5. Bayesian Markov Random Field analysis for protein function prediction based on network data. Kourmpetis YA, et al. PLoS One, 2010 Feb 24. PMID 20195360, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that in kinetochore mutants like ctf19 and mcm21 the protein is mislocalized. Furthermore, removal of Nkp2 in these mutants restores normal levels of segregation.
      Title: Yeast Nkp2 is required for accurate chromosome segregation and interacts with several components of the central kinetochore.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Mis6-Sim4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nkp2p
    NP_013419.1
    • Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      764808..765269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182204.1 → NP_013419.1  TPA: Nkp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYV9, Q06162
      UniProtKB/TrEMBL
      A0A8H4BXH2, A7A1K0, B3RHJ3, C7GUB6, C8ZDS8, G2WJD8
      Conserved Domains (1) summary
      pfam09447
      Location:3 → 66
      Cnl2_NKP2; Cnl2/NKP2 family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6NUW_J.1
    Q06162.1

    Gene LinkOut

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