Nmdar1 NMDA receptor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nmdar1provided by FlyBase
Official Full Name: NMDA receptor 1provided by FlyBase
Primary source: FLYBASE:FBgn0010399
Locus tag: Dmel_CG2902
See related: AllianceGenome:FB:FBgn0010399
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2902; DmelNmdar1; Dmel\CG2902; DMNMDAR1; DNmdar; dnmdar-I; DNMDAR-I; dNR1; DrNR1; dsNR1; NMDA; NMDA R1; NMDA-R1; Nmdar; NMDAR; nmdar1; NmdaR1; NMdar1; NMDAR1; nmr; nr1; NR1; NRI
Summary: Contributes to NMDA glutamate receptor activity. Involved in several processes, including behavioral response to ethanol; learning or memory; and sensory perception of touch. Located in postsynaptic membrane. Is integral component of membrane. Part of NMDA selective glutamate receptor complex. Is expressed in adult head; central nervous system; larval midline neurons; lateral cord neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 83A6-83A7; 3-47.5 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5508842..5523328, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1334564..1349050, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NMDA receptor regulates competition of epithelial cells in the Drosophila wing.
Title: The NMDA receptor regulates competition of epithelial cells in the Drosophila wing.
Study results suggest that D-serine made by intestinal serine racemase promotes sleep through NMDAR1 in Drosophila.
Title: D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep.
Recent studies indicate that several risk genes for schizophrenia are within two degrees of separation from the N-methy-D-aspartate receptor (NMDAR), a subtype of glutamate receptor that is critical to synapse formation and synaptic plasticity.[review]
Title: History of the Concept of Disconnectivity in Schizophrenia.
NMDAR1 promotes sleep regulation in Drosophila.
Title: The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster.
NMDA Receptor 1 plays a role in both behavioral responses to touch and in the formation of the actin-rich sensory filopodia.
Title: Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae.
The study suggested that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction.
Title: Mg(2+) block of Drosophila NMDA receptors is required for long-term memory formation and CREB-dependent gene expression.
Distribution of the NR1 subunit of the NMDA receptor in the cerebral ganglia of the honeybee and fruit fly are similar; areas with the highest concentrations of NR1 subunits were identified and compared.
Title: Comparative analysis of the locations of the NR1 and NR2 NMDA receptor subunits in honeybee (Apis mellifera) and fruit fly (Drosophila melanogaster, Canton-S wild-type) cerebral ganglia.
nmda receptor 1 regiure for long-term memory consolidation in Drosophila ellipsoid body.
Title: Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body.
NMDA receptor (dNR1) mediate associative olfactory learning and memory in Drosophila
Title: NMDA receptors mediate olfactory learning and memory in Drosophila.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of ionotropic glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NMDA receptor 1

Names: CG2902-PA; NMDA receptor; NMDA receptor I; NMDAR; Nmdar1-PA; dNR1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5508842..5523328 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169059.2 → NP_730940.1 NMDA receptor 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730940.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24418

Related

FBpp0078410

Conserved Domains (7) summary

cd06379
Location:12 → 405

PBP1_iGluR_NMDA_NR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR1, an essential channel-forming subunit of the NMDA receptor

COG0834
Location:451 → 558

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13719
Location:417 → 818

PBP2_iGluR_NMDA_Nr1; The ligand-binding domain of the NR1 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:575 → 838

Lig_chan; Ligand-gated ion channel

pfam01094
Location:58 → 371

ANF_receptor; Receptor family ligand binding region

pfam10562
Location:854 → 882

CaM_bdg_C0; Calmodulin-binding domain C0 of NMDA receptor NR1 subunit

cl21456
Location:516 → 651

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily