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    Sesn1 sestrin 1 [ Mus musculus (house mouse) ]

    Gene ID: 140742, updated on 21-Apr-2024

    Summary

    Official Symbol
    Sesn1provided by MGI
    Official Full Name
    sestrin 1provided by MGI
    Primary source
    MGI:MGI:2155278
    See related
    Ensembl:ENSMUSG00000038332 AllianceGenome:MGI:2155278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pa26; Sest1; 1110002G11Rik
    Summary
    Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and negative regulation of cell growth. Acts upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 16.1), large intestine adult (RPKM 14.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10 B2; 10 22.77 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41686570..41784432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41810574..41908436)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 162 Neighboring gene STARR-positive B cell enhancer ABC_E5128 Neighboring gene microRNA 3473b Neighboring gene centrosomal protein 57-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41472075-41472184 Neighboring gene cDNA sequence BC048559 Neighboring gene STARR-seq mESC enhancer starr_26466 Neighboring gene STARR-seq mESC enhancer starr_26467 Neighboring gene STARR-seq mESC enhancer starr_26468 Neighboring gene STARR-seq mESC enhancer starr_26469 Neighboring gene STARR-seq mESC enhancer starr_26471 Neighboring gene STARR-seq mESC enhancer starr_26472 Neighboring gene armadillo repeat containing 2 Neighboring gene annexin A2 pseudogene Neighboring gene predicted gene, 33058

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Clone Names

    • MGC118148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-leucine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-leucine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on peroxide as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to L-leucine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to leucine starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of response to reactive oxygen species IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of GATOR2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sestrin-1
    Names
    p53 regulated Pa26 nuclear protein
    p53-regulated protein PA26
    NP_001013388.2
    NP_001156380.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013370.2NP_001013388.2  sestrin-1 isoform 2

      See identical proteins and their annotated locations for NP_001013388.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK160083, BB338086, BC055753, BY126656
      Consensus CDS
      CCDS23809.1
      UniProtKB/Swiss-Prot
      E9QPK0, P58006, Q7TNF3
      UniProtKB/TrEMBL
      V5QRJ1
      Related
      ENSMUSP00000043034.7, ENSMUST00000041438.7
      Conserved Domains (1) summary
      pfam04636
      Location:47491
      PA26; PA26 p53-induced protein (sestrin)
    2. NM_001162908.1NP_001156380.1  sestrin-1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK160083, BB338086, BC100403
      Consensus CDS
      CCDS48550.1
      UniProtKB/TrEMBL
      E9PXR3, Q497S6
      Related
      ENSMUSP00000097515.4, ENSMUST00000099931.11
      Conserved Domains (1) summary
      pfam04636
      Location:106550
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      41686570..41784432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)