Slc25a4 solute carrier family 25 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a4provided by RGD
Official Full Name: solute carrier family 25 member 4provided by RGD
Primary source: RGD:620352
See related: Ensembl:ENSRNOG00000010830 AllianceGenome:RGD:620352
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ant1
Summary: Enables enzyme binding activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitochondrial membrane permeability involved in apoptotic process; and positive regulation of cell growth involved in cardiac muscle cell development. Located in membrane raft; mitochondrial inner membrane; and mitochondrial outer membrane. Biomarker of alcoholic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 24226.4), Muscle (RPKM 22345.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (52805521..52809316)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (46072935..46076730)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (49266903..49270698)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, peroxynitrite produced during cardiac ischemia and reperfusion injury can nitrate tyrosine residues of two key mitochondrial membrane proteins involved in bioenergetics and energy transfer via binding to hexokinase 2 to contribute to mitochondrial and cellular dysfunction.
Title: Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria.
ANT1 overexpression compensates impaired adenine nucleotide translocase activity under oxygen-restricted conditions
Title: Transgenic overexpression of adenine nucleotide translocase 1 protects ischemic hearts against oxidative stress.
Our data suggest that conformational changes of ANT may be directly involved in the opening of the Tl(+)-induced mitochondrial permeability transition pore in the inner membrane of Ca(2+)-loaded rat liver mitochondria
Title: To involvement the conformation of the adenine nucleotide translocase in opening the Tl(+)-induced permeability transition pore in Ca(2+)-loaded rat liver mitochondria.
Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia
Title: Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia via increased ERK1/2 and AKT activation.
The findings reported in this paper demonstrate that ADP inhibits the proapoptotic stimulus supposedly via: i) inhibition of ROS production during early stages of apoptosis, an effect mediated by its interaction with cell receptor/s.
Title: Extracellular ADP prevents neuronal apoptosis via activation of cell antioxidant enzymes and protection of mitochondrial ANT-1.
carbon monoxide protects astrocytes from apoptosis by preventing MMP, acting on ANT (glutathionylation and inhibition of its pore activity) via a preconditioning-like process mediated by ROS and GSSG
Title: Glutathionylation of adenine nucleotide translocase induced by carbon monoxide prevents mitochondrial membrane permeabilization and apoptosis.
These data suggest a likely enzymatic involvement in the interaction between ANT and coenzyme A.
Title: Coenzyme A enhances activity of the mitochondrial adenine nucleotide translocator.
The target site for Cu(2+) is located in the ADP/ATP carrier.
Title: Copper induces permeability transition through its interaction with the adenine nucleotide translocase.
apoptosis of cardiomyocytes is an important regulatory mechanism that is involved in the cardiac adaptive response to pressure overload, and the apoptosis of cardiomyocytes is mediated, in part, by ANT1
Title: Apoptosis in pressure overload-induced cardiac hypertrophy is mediated, in part, by adenine nucleotide translocator-1.
These data suggest that hepatic accumulation of fat impairs mitochondrial function, reflecting the loss of oxidative phosphorylation capacity caused by a decrease in the ANT content.
Title: Decreased ANT content in Zucker fatty rats: relevance for altered hepatic mitochondrial bioenergetics in steatosis.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:141081

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:141083

SLC25A4 (e-PCR)
- UniSTS:266054

D4S3175 (e-PCR)
- UniSTS:16763

RH142319 (e-PCR)
- UniSTS:231566

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	IEA Inferred from Electronic Annotation more info
enables ATP:ADP antiporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:ADP antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidative phosphorylation uncoupler activity	IEA Inferred from Electronic Annotation more info
enables oxidative phosphorylation uncoupler activity	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP transport	ISO Inferred from Sequence Orthology more info
involved_in ADP transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in adaptive thermogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic mitochondrial changes	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic mitochondrial changes	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial ADP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ADP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ADP transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial ATP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial permeability transition pore complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial permeability transition pore complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP/ATP translocase 1

Names: ADP,ATP carrier protein 1; ANT 1; adenine nucleotide translocator 1; adenine nucleotide translocator), member 4; mitochondrial adenine nucleotide translocator; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053515.2 → NP_445967.2 ADP/ATP translocase 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q05962

UniProtKB/TrEMBL

F7FMU8, Q6P9Y4

Related

ENSRNOP00000014704.2, ENSRNOT00000014704.5

Conserved Domains (1) summary

PTZ00169
Location:2 → 298

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional