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    lin-17 Frizzled-4 [ Caenorhabditis elegans ]

    Gene ID: 171832, updated on 23-Nov-2023

    Summary

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    Gene symbol
    lin-17
    Gene description
    Frizzled-4
    Primary source
    WormBase:WBGene00003006
    Locus tag
    CELE_Y71F9B.5
    See related
    AllianceGenome:WB:WBGene00003006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables receptor tyrosine kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; axis specification; and generation of neurons. Located in neuron projection membrane. Is expressed in several structures, including P3.p male; P4.p male; epithelial cell; male-specific anatomical entity; and neurons. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (2707598..2717549)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene arginine kinase Neighboring gene ncRNA Neighboring gene J domain-containing protein Neighboring gene Cyclin N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions. Sternberg PW, et al. Dev Biol, 1988 Nov. PMID 3181641
    2. The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans. Steimel A, et al. Development, 2010 Nov. PMID 20876647, Free PMC Article
    3. A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons. Maro GS, et al. PLoS One, 2009. PMID 19259273, Free PMC Article
    4. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Sawa H, et al. Genes Dev, 1996 Sep 1. PMID 8804313
    5. Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Bargmann CI, et al. Neuron, 1991 Nov. PMID 1660283

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIN-17 and DSH-1/Dishevelled proteins were recruited to the pruning neurites in lin-44-dependent manners.
      Title: Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans.
    2. Loss of the Frizzled receptor LIN-17 or the planar cell polarity (PCP) protein VANG-1 also caused cross over defects that did not enhance those in the cam-1 mutant, indicating that the proteins function together in midline guidance.. Strong cam-1 expression can be detected in the PVQs and the guidepost cell PVT that is located on the midline
      Title: Regulation of Axon Guidance by the Wnt Receptor Ror/CAM-1 in the PVT Guidepost Cell in Caenorhabditis elegans.
    3. LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.
      Title: LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons.
    4. lin-17 (Frizzled type Wnt receptor) and lin-18 (Ryk) regulate the pattern of POP-1 localization and cell type specification in the posterior half of the vulva.
      Title: lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development.
    5. a novel planar cell polarity (PCP)-like pathway, in which LIN-17 and MIG-5 are asymmetrically localized, is involved in the regulation of B cell polarity
      Title: Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in anterior/posterior axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of anatomical structure orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of anatomical structure orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interneuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in interneuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interneuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polarity specification of anterior/posterior axis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polarity specification of proximal/distal axis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polarity specification of proximal/distal axis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of motor neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Frizzled-4
    NP_001021813.1
    • Confirmed by transcript evidence
    NP_001293367.1
    • Confirmed by transcript evidence
    NP_491028.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2707598..2717549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058627.7 → NP_491028.2  Frizzled-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491028.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y45
      Conserved Domains (2) summary
      cd07454
      Location:25 → 144
      CRD_LIN_17; Cysteine-rich domain (CRD) of LIN_17
      pfam01534
      Location:195 → 506
      Frizzled; Frizzled/Smoothened family membrane region

    2. NM_001026642.6 → NP_001021813.1  Frizzled-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDV1
      Conserved Domains (2) summary
      cd07454
      Location:25 → 144
      CRD_LIN_17; Cysteine-rich domain (CRD) of LIN_17
      pfam01534
      Location:195 → 506
      Frizzled; Frizzled/Smoothened family membrane region

    3. NM_001306438.3 → NP_001293367.1  Frizzled-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A078BS14
      Conserved Domains (2) summary
      pfam01534
      Location:127 → 438
      Frizzled; Frizzled/Smoothened family membrane region
      cl02447
      Location:1 → 76
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    RNA

    1. NR_131370.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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