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    deoA thymidine phosphorylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948901, updated on 4-Apr-2024

    Summary

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    Gene symbol
    deoA
    Gene description
    thymidine phosphorylase
    Primary source
    ASAP:ABE-0014374
    Locus tag
    b4382
    See related
    ECOCYC:EG10219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4374; TP; tpp; ttg
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    Genomic context

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    Sequence:
    NC_000913.3 (4618229..4619551)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative glycyl-radical enzyme activating enzyme YjjW Neighboring gene DUF3029 domain-containing protein YjjI Neighboring gene deoxyribose-phosphate aldolase Neighboring gene phosphopentomutase Neighboring gene purine nucleoside phosphorylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives. Petaccia M, et al. Colloids Surf B Biointerfaces, 2016 Apr 1. PMID 26752208
    2. Substrate specificity of thymidine phosphorylase of E. coli: role of hydroxyl groups. Panova NG, et al. Nucleosides Nucleotides Nucleic Acids, 2008 Dec. PMID 19003566
    3. Substrate specificity of Escherichia coli thymidine phosphorylase. Panova NG, et al. Biochemistry (Mosc), 2007 Jan. PMID 17309433
    4. Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compounds. Liekens S, et al. Nucleosides Nucleotides Nucleic Acids, 2006. PMID 17065049
    5. Thymidine phosphorylase from Escherichia coli: tight-binding inhibitors as enzyme active-site titrants. Gbaj A, et al. J Enzyme Inhib Med Chem, 2006 Feb. PMID 16570508

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that thymidine phosphorylase enzymatic phosphorolysis of thymidine was reduced by 5-fluoruracil derivatives.
      Title: Kinetics and mechanistic study of competitive inhibition of thymidine phosphorylase by 5-fluoruracil derivatives.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrimidine-nucleoside phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thymidine phosphorylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleoside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in thymidine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    thymidine phosphorylase
    NP_418799.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4618229..4619551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418799.1 thymidine phosphorylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418799.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AB86, A0A827YB37, A0A828PL53, A0AA87EY36
      Conserved Domains (1) summary
      PRK05820
      Location:1 → 440
      deoA; thymidine phosphorylase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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