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    RRM3 DNA helicase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856426, updated on 13-Apr-2024

    Summary

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    Gene symbol
    RRM3
    Gene description
    DNA helicase
    Primary source
    SGD:S000001073
    Locus tag
    YHR031C
    See related
    AllianceGenome:SGD:S000001073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RTT104
    Summary
    Enables DNA helicase activity. Involved in several processes, including G-quadruplex DNA unwinding; cellular macromolecule biosynthetic process; and replication fork progression beyond termination site. Located in nuclear replication fork. Orthologous to human PIF1 (PIF1 5'-to-3' DNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (170799..172970, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Yhi9p Neighboring gene mitogen-activated serine/threonine-protein kinase SLT2 Neighboring gene Erc1p Neighboring gene putative glutamate 5-kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stimulation of direct-repeat recombination by RNA polymerase III transcription. de la Loza MC, et al. DNA Repair (Amst), 2009 May 1. PMID 19168400
    2. Impairment of replication fork progression mediates RNA polII transcription-associated recombination. Prado F, et al. EMBO J, 2005 Mar 23. PMID 15775982, Free PMC Article
    3. Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Makovets S, et al. Mol Cell Biol, 2004 May. PMID 15082794, Free PMC Article
    4. Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Ivessa AS, et al. Genes Dev, 2002 Jun 1. PMID 12050116, Free PMC Article
    5. Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes. Deegan TD, et al. Mol Cell, 2019 Apr 18. PMID 30850330, Free PMC Article

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The increase in cell death rates in caloric restricted cells of the yeast helicase mutant rrm3 is Sir complex dependent.
      Title: The increase in cell death rates in caloric restricted cells of the yeast helicase mutant rrm3 is Sir complex dependent.
    2. Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
      Title: Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
    3. Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae.
      Title: Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae.
    4. Pif1 family helicases promote mutation avoidance during DNA replication.
      Title: Pif1 family helicases promote mutation avoidance during DNA replication.
    5. Suppression of chromosome instability by targeting a DNA helicase in budding yeast.
      Title: Suppression of chromosome instability by targeting a DNA helicase in budding yeast.
    6. We showed that the Pif1 and Rrm3 DNA helicases promote efficient fork convergence and completion of DNA synthesis, even in the absence of type II topoisomerase. Furthermore, Rrm3 and Pif1 are also important for termination of plasmid DNA replication in vivo.
      Title: Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes.
    7. The absence of Rrm3 renders cells resistant to microtubule-destabilizing drugs.
      Title: Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae.
    8. It has been proposed that Rrm3 and Pif1 promote genome stability at tDNAs by displacing the stable multi-protein transcription complex and by removing R-loops.
      Title: PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.
    9. Either Pif1 or Rrm3 redundantly stimulates strand displacement by DNA polymerase delta during lagging-strand synthesis.
      Title: Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes.
    10. Rrm3 recruitment to replication-born DSBs is crucial for viability.
      Title: A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G-quadruplex DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables centromeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G-quadruplex DNA unwinding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G-quadruplex DNA unwinding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in replication fork progression beyond termination site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork reversal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork reversal IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in replication fork IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in replication fork IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA helicase
    NP_011896.1
    • DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; deletion or inactivation of helicase function suppresses chromosome instability (CIN) associated with centromere or kinetochore defects; structurally and functionally related to Pif1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      170799..172970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179161.1 → NP_011896.1  TPA: DNA helicase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKX8, P38766
      UniProtKB/TrEMBL
      A0A8H4C0L5, N1P392
      Conserved Domains (2) summary
      COG0507
      Location:37 → 723
      RecD; ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I [Replication, recombination and repair]
      cd18037
      Location:235 → 414
      DEXSc_Pif1_like; DEAD-box helicase domain of Pif1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38766.1

    Gene LinkOut

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