UGA2 succinate-semialdehyde dehydrogenase (NAD(P)(+)) [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: UGA2
Gene description: succinate-semialdehyde dehydrogenase (NAD(P)(+))
Primary source: SGD:S000000210
Locus tag: YBR006W
See related: AllianceGenome:SGD:S000000210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: UGA5
Summary: Enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity. Involved in cellular response to oxidative stress; gamma-aminobutyric acid catabolic process; and glutamate decarboxylation to succinate. Located in cytoplasm. Human ortholog(s) of this gene implicated in succinic semialdehyde dehydrogenase deficiency. Orthologous to human ALDH5A1 (aldehyde dehydrogenase 5 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

GAD1, UGA1 and UGA2 mediates thermotolerance by reducing reactive oxygen production.
Title: GABA shunt mediates thermotolerance in Saccharomyces cerevisiae by reducing reactive oxygen production.
UGA1 and UGA2, are subject to amino acid regulation as it occurs for UGA4.
Title: Common features and differences in the expression of the three genes forming the UGA regulon in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-semialdehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate decarboxylation to succinate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutamate decarboxylation to succinate	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

NP_009560.1

Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm