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Series GSE58122 Query DataSets for GSE58122
Status Public on Oct 01, 2015
Title Serial RNA-seq of a single human
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Psychiatric disorders are characterized by major fluctuations in psychological function over the course of weeks and months, but the dynamic characteristics of human brain function over this timescale in healthy individuals are unknown. Over a period of 18 months, we performed intensive phenome-wide assessment of a single human, including brain connectivity using resting fMRI, measurements of psychological and physical health, and transcriptomic and metabolomic profiling.
Brain connectivity varied across sessions in relation to behavioral variables including mood, fatigue, and food/caffeine intake, as well as variables related to inflammation and gut health. Pathway-based analysis of gene expression in peripheral lymphocytes identified associations with physical health and brain connectivity, including associations between specific brain networks and a broad set of immune-related pathways. Metabolomic measures were strongly associated with dietary variance.
This study integrates dense neuroimaging and -omics profiling to provide a detailed picture of the joint dynamics of human brain and metabolic function over time, an approach that is critical for the understanding of brain disorders characterized by increased variability of brain function.

Overall design Repeated measures on a single individual;
RNA was extracted from PBMCs from a single human repeatedly over the course of 18 months, under fasted conditions at a consistent time of day. This was collected along side a large number of other variables including brain imaging.
More information is available at
Web link
Contributor(s) Poldrack R
Citation(s) 26648521
Submission date May 30, 2014
Last update date May 15, 2019
Contact name Russell Poldrack
Phone 15122329504
Organization name University of Texas at Austin
Street address 100 East 24th Street, R9975
City Austin
State/province TX
ZIP/Postal code 78712
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (48)
GSM1401303 sub002
GSM1401320 sub007
GSM1401321 sub009
BioProject PRJNA249059
SRA SRP042596

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE58122_varstab_data_prefiltered_geo.txt.gz 4.9 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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