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Series GSE95822 Query DataSets for GSE95822
Status Public on Feb 06, 2019
Title Length-independent telomere damage drives cardiomyocyte senescence
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Ageing is the biggest risk factor to cardiovascular health and is associated with increased incidence of cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening has been implicated in age-related cardiac dysfunction. However, the role of cellular senescence and its underlying mechanisms in slowly dividing/post-mitotic cardiomyocytes is not understood.
Overall design We quantify transcription via high throughput RNA sequencing in young (3 months) and old (20 months) mouse cardiomyocytes.
Contributor(s) Anderson R, Maggiorani D, Robertson NA, Mialet-Perez J, Richardson GD, Passos JF
Citation(s) 30737259
Submission date Mar 08, 2017
Last update date May 15, 2019
Contact name Neil A Robertson
Organization name University of Edinburgh
Department Institute of Cancer and Genetics
Lab Tamir Chandra
Street address Crewe Road, Western General Hospital Campus
City Edinburgh
State/province Lothian
ZIP/Postal code EH4 2XU
Country United Kingdom
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (10)
GSM2526518 Young Rep1
GSM2526519 Young Rep2
GSM2526520 Young Rep3
BioProject PRJNA378524
SRA SRP101569

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE95822_DESeq2.Old-vs-Young-Comparison.xlsx 5.5 Mb (ftp)(http) XLSX
GSE95822_FPKM_Matrix.xlsx 2.7 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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