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| Status |
Public on Feb 06, 2019 |
| Title |
Length-independent telomere damage drives cardiomyocyte senescence |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Ageing is the biggest risk factor to cardiovascular health and is associated with increased incidence of cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening has been implicated in age-related cardiac dysfunction. However, the role of cellular senescence and its underlying mechanisms in slowly dividing/post-mitotic cardiomyocytes is not understood.
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| Overall design |
We quantify transcription via high throughput RNA sequencing in young (3 months) and old (20 months) mouse cardiomyocytes.
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| Contributor(s) |
Anderson R, Maggiorani D, Robertson NA, Mialet-Perez J, Richardson GD, Passos JF |
| Citation(s) |
30737259 |
| Submission date |
Mar 08, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Neil A Robertson |
| E-mail(s) |
neil.alistair.robertson@hotmail.co.uk
|
| Organization name |
University of Edinburgh
|
| Department |
Institute of Cancer and Genetics
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| Lab |
Tamir Chandra
|
| Street address |
Crewe Road, Western General Hospital Campus
|
| City |
Edinburgh |
| State/province |
Lothian |
| ZIP/Postal code |
EH4 2XU |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA378524 |
| SRA |
SRP101569 |
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