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Series GSE93825 Query DataSets for GSE93825
Status Public on Jun 18, 2018
Title Gene expression profiling in human ACTH-secreting pituitary tumors
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Corticotropin (ACTH)-secreting pituitary adenomas give rise to a severe endocrinological disorder, i.e., Cushing’s disease, with multifaceted clinical presentation and treatment outcomes. Experimental studies suggested that disease variability is inherent to the pituitary tumor, thus pointing to the need for further studies into tumor biology. Aim of the present study was to evaluate transcriptome expression pattern in a large series of ACTH-secreting pituitary adenoma specimens, in order to identify molecular signatures of these tumors. Gene expression profiling of formalin-fixed paraffin-embedded specimens from 40 human ACTH-secreting pituitary adenomas revealed significant expression of genes involved in protein biosynthesis and ribosomal function, in keeping with neuroendocrine cell profile. Unsupervised cluster analysis identified three distinct gene profile clusters and several genes were uniquely overexpressed in a given cluster, accounting for different molecular signatures. Of note, gene expression profiles were associated with clinical features such as age and size of the tumor. Altogether, our study shows that corticotrope tumors are characterized by neuroendocrine gene expression profile and present subgroup-specific molecular features.
 
Overall design gene expression analysis of 40 RNA obtained from formalin-fixed paraffin-embedded pituitary human tissue
 
Contributor(s) Cassarino MF, Ambrogio AG, Cassarino A, Terreni MR, Gentilini D, Losa M, Sesta A, Cavagnini F, Pecori Giraldi F
Citation(s) 29920815, 31280266
Submission date Jan 19, 2017
Last update date Feb 03, 2020
Contact name Francesca Pecori Giraldi
Organization name Istituto Auxologico Italiano
Department Neuroendocrinology Research Laboratory
Street address via Zucchi 18
City Cusano Milanino
State/province Milan
ZIP/Postal code 20095
Country Italy
 
Platforms (1)
GPL18281 Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip [gene symbol version]
Samples (40)
GSM2463039 Patient 1_Neuroendocrine tissue
GSM2463040 Patient 2_Neuroendocrine tissue
GSM2463041 Patient 3_Neuroendocrine tissue
Relations
BioProject PRJNA362538

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE93825_RAW.tar 77.6 Mb (http)(custom) TAR (of IDAT)
GSE93825_non_normalized.txt.gz 5.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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