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Series GSE54568 Query DataSets for GSE54568
Status Public on May 16, 2014
Title Expression data from human brain dorsolateral prefrontal cortex - including control samples and samples with major depression disorders (30 samples BA9_F)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mechanisms. As systematic dataset integration is becoming essential, we developed methods and performed meta-clustering of gene coexpression links in 11 transcriptome studies from postmortem brains of human subjects with major depressive disorder (MDD) and non-psychiatric control subjects. We next sought enrichment in the top 50 meta-analyzed coexpression modules for genes otherwise identified by GWAS for various sets of disorders. One coexpression module of 88 genes was consistently and significantly associated with GWAS for MDD, other neuropsychiatric disorders and brain functions, and for medical illnesses with elevated clinical risk of depression, but not for other diseases (See publication for details).
 
Overall design 30 total samples in 15 pairs were analyzed in postmortem tissue from the dorsolateral prefrontal cortex.
 
Contributor(s) Sibille E
Citation(s) 24608543
Submission date Jan 30, 2014
Last update date Mar 25, 2019
Contact name Etienne Sibille
E-mail(s) etienne.sibille@camh.ca
Phone 412-624-0804
Organization name University of Pittsburgh
Department Psychiatry
Street address 450 Technology Drive, Suite 231
City Pittsburgh
State/province PA
ZIP/Postal code 15219
Country USA
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (30)
GSM1319078 Control matched sample pair brain dorsolateral prefrontal cortex BA9_F #3
GSM1319079 Control matched sample pair brain dorsolateral prefrontal cortex BA9_F #5
GSM1319080 Control matched sample pair brain dorsolateral prefrontal cortex BA9_F #6
Relations
BioProject PRJNA237169

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Supplementary file Size Download File type/resource
GSE54568_RAW.tar 149.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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