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Series GSE54563 Query DataSets for GSE54563
Status Public on May 16, 2014
Title Expression data from human brain anterior cingulate cortex - including control samples and samples with major depression disorders (50 samples MD3_ACC)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mechanisms. As systematic dataset integration is becoming essential, we developed methods and performed meta-clustering of gene coexpression links in 11 transcriptome studies from postmortem brains of human subjects with major depressive disorder (MDD) and non-psychiatric control subjects. We next sought enrichment in the top 50 meta-analyzed coexpression modules for genes otherwise identified by GWAS for various sets of disorders. One coexpression module of 88 genes was consistently and significantly associated with GWAS for MDD, other neuropsychiatric disorders and brain functions, and for medical illnesses with elevated clinical risk of depression, but not for other diseases (See publication for details).
 
Overall design 50 total samples in 25 pairs were analyzed in postmortem tissue from the anterior cingulate cortex.
 
Contributor(s) Sibille E
Citation(s) 24608543
Submission date Jan 30, 2014
Last update date Aug 16, 2018
Contact name Etienne Sibille
E-mail(s) etienne.sibille@camh.ca
Phone 412-624-0804
Organization name University of Pittsburgh
Department Psychiatry
Street address 450 Technology Drive, Suite 231
City Pittsburgh
State/province PA
ZIP/Postal code 15219
Country USA
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (50)
GSM1318898 MDD matched sample pair anterior cingulate cortex MD3_ACC #14
GSM1318899 MDD matched sample pair anterior cingulate cortex MD3_ACC #15
GSM1318900 MDD matched sample pair anterior cingulate cortex MD3_ACC #16
Relations
BioProject PRJNA237168

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE54563_RAW.tar 6.2 Mb (http)(custom) TAR
GSE54563_non-normalized.txt.gz 3.5 Mb (ftp)(http) TXT
Processed data included within Sample table
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