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Series GSE97932 Query DataSets for GSE97932
Status Public on Jan 01, 2020
Title Cell-free DNA methylation markers in diagnosis and prognosis of common cancers (lung cancer)
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary To identify diagnostic and prognostic biomarkers, we compared methylation profiles of LUNC tissues and normal blood at 485,000 CpG markers and identified a marker panel differently methylated in LUNC. We developed diagnostic and prognostic prediction models with the selected panel and compared their efficacy in ctDNA to current available approaches. Our data indicate that cfDNA methylation patterns provide reliable biomarkers in the diagnosis, surveillance, and prognosis of LUNC.
Overall design Base-pair resolution DNA methylation across 888 genomic ~100bp regions was analyzed in circulating tumor DNA (ctDNA) extracted from serum of 654 lung cancer patients
Contributor(s) Krawczyk M, Wang W, Flagg K, Zhang K
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Submission date Apr 18, 2017
Last update date Jan 01, 2020
Contact name Kang Zhang
Organization name UCSD
Street address 9500 Gilman Dr
City La Jolla
ZIP/Postal code 92093
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (654)
GSM2581301 LUNC.ct-1
GSM2581302 LUNC.ct-2
GSM2581303 LUNC.ct-3
BioProject PRJNA383370
SRA SRP104169

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE97932_KangZhang_et.all_2017_processed_LUNC_data.txt.gz 1.2 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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