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Series GSE97923 Query DataSets for GSE97923
Status Public on Jan 01, 2020
Title Cell-free DNA methylation markers in diagnosis and prognosis of common cancers (COAD)
Organism Homo sapiens
Experiment type Methylation profiling by high throughput sequencing
Summary To identify diagnostic and prognostic biomarkers, we compared methylation profiles of COAD tissues and normal blood at 485,000 CpG markers and identified a marker panel differently methylated in COAD. We developed diagnostic and prognostic prediction models with the selected panel and compared their efficacy in ctDNA to current available approaches. Our data indicate that cfDNA methylation patterns provide reliable biomarkers in the diagnosis, surveillance, and prognosis of COAD.
Overall design Base-pair resolution DNA methylation across 888 genomic ~100bp regions was analyzed in circulating tumor DNA (ctDNA) extracted from serum of 773 colon cancer patients
Contributor(s) Krawczyk M, Wang W, Flagg K, Zhang K
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Submission date Apr 18, 2017
Last update date Jan 01, 2020
Contact name Kang Zhang
Organization name UCSD
Street address 9500 Gilman Dr
City La Jolla
ZIP/Postal code 92093
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (773)
GSM2580347 COAD.ct-1
GSM2580348 COAD.ct-2
GSM2580349 COAD.ct-3
BioProject PRJNA383358
SRA SRP104168

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE97923_KangZhang_et.all_2017_processed_COAD_data.txt.gz 1.3 Mb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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