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Series GSE97177 Query DataSets for GSE97177
Status Public on Mar 30, 2017
Title Genome-wide multi-omics profiling reveals extensive genetic complexity in 8p11-p12 amplified breast carcinomas [expression]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Transcriptomic profiling of human breast tumors.

Genomic and expression profiling using 38K BAC array-CGH and Illumina HT-12 beadchips were performed on 53 invasive breast tumors to assess the impact of gene dosage on gene expression patterns and the effect of other mechanisms on transcriptional levels. Array-CGH results was validated by FISH using tumors showing 8p11-p12 DNA amplification and expression profiling was confirmed using qPCR for 11 transcripts. Low-level gain, high-level gain/amplification, heterozygous loss and homozygous deletion (henceforth referred to as gain, amplification, loss and deletion) were defined as log2 ratio thresholds set at +0.2, >= +0.5, -0.2 and <=-1.0, respectively.
 
Overall design Total RNA was isolated from fresh-frozen tissue samples
 
Contributor(s) Parris TZ, Rönnerman EW, Engqvist H, Biermann J, Truvé K, Nemes S, Forssell-Aronsson E, Kovács A, Karlsson P, Helou K
Citation(s) 20551037, 24662924, 28877888
Submission date Mar 29, 2017
Last update date Apr 17, 2019
Contact name Toshima Z. Parris
E-mail toshima.parris@oncology.gu.se
Organization name University of Gothenburg
Department Department of Oncology
Lab Sahlgrenska Cancer Center
Street address Medicinaregatan 1G, 6th floor
City Gothenburg
ZIP/Postal code 41390
Country Sweden
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (53)
GSM2556314 Tumor_4296 (expr)
GSM2556316 Tumor_4302 (expr)
GSM2556318 Tumor_5582 (expr)
This SubSeries is part of SuperSeries:
GSE97293 Genome-wide multi-omics profiling reveals extensive genetic complexity in 8p11-p12 amplified breast carcinomas
Relations
BioProject PRJNA380897

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE97177_Non-normalized_data.txt.gz 7.8 Mb (ftp)(http) TXT
GSE97177_RAW.tar 119.0 Mb (http)(custom) TAR (of IDAT)
Raw data provided as supplementary file
Processed data included within Sample table
Raw data is available on Series record

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