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Series GSE9630 Query DataSets for GSE9630
Status Public on Nov 17, 2007
Title Expression data from mouse liver
Organism Mus musculus
Experiment type Expression profiling by array
Summary Exposure to high levels of arsenic in drinking water is associated with several types of cancers including lung, bladder and skin, as well as vascular disease and diabetes. Drinking water standards are based primarily on epidemiology and extrapolation from higher dose experiments, rather than measurements of phenotypic changes associated with chronic exposure to levels of arsenic similar to the current standard of 10ppb, and little is known about the difference between arsenic in food as opposed to arsenic in water. Measurement of phenotypic changes at low doses may be confounded by the effect of laboratory diet, in part because of trace amounts of arsenic in standard laboratory chows, but also because of broad metabolic changes in response to the chow itself. Finally, this series contrasts 8hr, 1mg/kg injected arsenic with the various chronic exposures, and also contrasts the acute effects of arsenic, dexamethasone or their combination. Male C57BL/6 mice were fed on two commercially available laboratory diets (LRD-5001 and AIN-76A) were chronically exposed, through drinking water or food, to environmentally relevant concentrations of sodium arsenite, or acutely exposed to dexamethasone.
Keywords: dose response
Overall design Male C57BL/6 mice, fed on two commercially available laboratory diets (LRD-5001 and AIN-76A), were chronically exposed through drinking water or food, to environmentally relevant concentrations of sodium arsenite.
Another group animals, fed on the AIN 76A diet, was IP injected with dexamethasone (1 mg/kg), sodium arsenite (1mg/kg), both dexamethosone and arsenite, or saline alone.
Contributor(s) Ihnat MA, Hamilton JW
Citation(s) 18396267
Submission date Nov 16, 2007
Last update date Feb 11, 2019
Contact name Thomas H Hampton
Organization name Geisel School of Medicine at Dartmouth
Department Microbiology Immunology
Lab Stanton
Street address North College Street
City Hanover
State/province NH
ZIP/Postal code 03755
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (59)
GSM243352 Mouse Liver AIN Diet 8hr Saline Injection, biological replicate B
GSM243353 Mouse Liver AIN Diet 5wk 100ppb As Drinking Water Expousre, biological replicate D
GSM243354 Mouse Liver LRD Diet 5wk 100ppb Drinking Water Exposure, biological replicate A
BioProject PRJNA103481

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9630_RAW.tar 189.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Raw data provided as supplementary file
Processed data provided as supplementary file

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