|
| Status |
Public on Feb 14, 2018 |
| Title |
RNAseq data from Mesenchymal stem cells treated with TCDD or 1-methyl tryptophan |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Whole genome RNA-sequencing identified Nrf2, MAPK12 and IL-1a as important downstream targets of 1MT. We further demonstrate 1a1 and 1b1 activation by 1MT in IDO+ MSC following interferon-γ (IFNγ) activation, suggestive that 1MT-driven AHR signaling is uncoupled from IDO catalytic function. These observations support a novel paradigm by which AHR-activating compounds like 1MT can be used in cancer immunotherapy to stimulate a pro-inflammatory response, activating the body’s immune system to infiltrate and eradicate tumors.
|
| |
|
| Overall design |
RNAseq analysis of MSCs to a common AHR ligand (TCDD) and comparisons with 1MT, to elucidate common signaling modalities.
|
| |
|
| Contributor(s) |
Lewis C, Galipeau J, Bosinger S, Tharp G |
| Citation(s) |
29190885 |
| |
| Submission date |
Feb 19, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Gregory K Tharp |
| E-mail(s) |
gktharp@emory.edu
|
| Phone |
404-727-7797
|
| Organization name |
Yerkes National Primate Research Center
|
| Department |
Developmental and Cognitive Neuroscience
|
| Lab |
Genomics Core
|
| Street address |
954 Gatewood Dr
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30329-4208 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (15)
|
|
| Relations |
| BioProject |
PRJNA375931 |
| SRA |
SRP100320 |
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