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Series GSE94958 Query DataSets for GSE94958
Status Public on Feb 22, 2018
Title Identification of the RB loss-induced E2F1 cistrome in prostate cancer [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The retinoblastoma protein (RB) is preferentially lost in the progression to castrate resistant prostate cancer (CRPC). However, the alterations associated with such loss have been scantly described. The current study aims to provide molecular mechanisms underlying Rb loss-driven CRPC phenotypes.
Overall design Alterations in E2F1 binding upon RB loss were assessed in hormone deficient conditions through ChIP-Seq of shCON and shRB LNCaP prostate cancer cells.
Contributor(s) Knudsen KE, McNair C
Citation(s) 29202480
Submission date Feb 15, 2017
Last update date May 15, 2019
Contact name Christopher McNair
Organization name Thomas Jefferson University
Department Cancer Biology
Lab Knudsen Lab
Street address 1028A BLSB 233 South 10th Street
City Philadelphia
State/province PA
ZIP/Postal code 19107
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (2)
GSM2492420 LN shRB E2F1 CDT ChIP-Seq
GSM2492421 LN shCON E2F1 CDT ChIP-Seq
This SubSeries is part of SuperSeries:
GSE94959 Identification of the RB loss-induced transcriptome and E2F1 cistrome in prostate cancer
BioProject PRJNA374919
SRA SRP099930

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Supplementary file Size Download File type/resource
GSE94958_RAW.tar 610.0 Kb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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