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Series GSE94637 Query DataSets for GSE94637
Status Public on Jun 17, 2017
Title Expression profiling of NMuMG progression series
Organism Mus musculus
Experiment type Expression profiling by array
Summary We have developed a progression series of increasingly metastatic cell lines generated from the normal mammary epithelial cell line, NMuMG, to distinguish between early changes in cancer initiation and metastasis-promoting alterations.
Overall design In the absence of hnRNP E1 expression, NMuMG cells become both tumorigenic and metastatic, with metastases identified in the lungs of mammary fat pad injected NOD/SCID mice. The metastatic potential of the E1KD cell line can be enhanced by in vivo passaging which allows for the artificial selection of cells capable of forming primary tumors and lung metastases. This technique led to the isolation of increasingly aggressive metastatic cell lines, termed L1P and L2P that metastasize to lung. In addition, the M1P cell line were isolated from a primary mammary tumor.
Contributor(s) Howley BV, Link LA, Grelet S, El-Sabban M, Howe PH
Citation(s) 28825698
Submission date Feb 07, 2017
Last update date Oct 11, 2019
Contact name Philip H Howe
Organization name Medical University of South Carolina
Department Biochemistry
Street address 173 Ashley Avenue
City Charleston
State/province South Carolina
ZIP/Postal code 29425
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (15)
GSM2479946 NMuMG replicate 1
GSM2479947 NMuMG replicate 2
GSM2479948 NMuMG replicate 3
BioProject PRJNA371643

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Supplementary file Size Download File type/resource
GSE94637_RAW.tar 49.4 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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