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Series GSE9338 Query DataSets for GSE9338
Status Public on Jan 19, 2008
Title Expression data from Mus musculus subspecies and their F1 hybrids for 3 tissues (brain, liver, testis)
Platform organism Mus musculus
Sample organisms Mus musculus castaneus; Mus musculus domesticus; Mus musculus musculus; Mus musculus musculus x M. m. domesticus; Mus musculus musculus x M. m. castaneus
Experiment type Expression profiling by array
Summary We have studied different subspecies of the house mouse (M. m. musculus, M. m. domesticus and M. m. castaneus) and their reciprocal F1 hybrids to estimate the within-locus mode of inheritance for subspecies differences in gene expression in three tissues (brain, liver, testis) of male mice. This study investigates mode of inheritance in crosses at a larger taxonomic distance than have been previously systematically investigated. We found the vast majority of transcripts to be additively expressed with only a few transcripts showing dominance or overdominance in expression, except for one direction of one cross, which showed large mis-expression in the testis.
Keywords: comparative whole transcripome analysis
 
Overall design Wild-derived inbred lines of M. m. musculus, M. m. domesticus and M. m. castaneus were used to generate reciprocal crosses of M. m. musculus x M. m. domesticus and M. m. musculus x M. m. castaeneus. The gene expression profile of 2 males each of the hybrids and the pure parental subspecies were analyzed by using the Affymetrix GeneChip 430 2.0 to obtain evidence about the within-locus mode of inheritance of genes. First, we studied all transcripts that are differentially expressed between the parental subspecies and assessed additivity vs. nonadditivity of expression of these transcripts in the F1 hybrids. Second, we investigated those transcripts which do not differ in expression between the parental lines, but which are expressed differently in the F1 hybrids relative to both of their parents.
 
Contributor(s) Rottscheidt R, Harr B
Citation(s) 17947435
Submission date Oct 16, 2007
Last update date Feb 11, 2019
Contact name Ruth Rottscheidt
E-mail(s) ruth.rottscheidt@uni-koeln.de
Organization name University of Cologne
Department Institute for Genetics
Lab Tautz Harr Mouse Evolutionary Genomics
Street address Zuelpicher Strasse 47
City Cologne
ZIP/Postal code 50674
Country Germany
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (42)
GSM237747 domesticus male 1, biological rep1, brain
GSM237748 domesticus male 2, biological rep2, brain
GSM237749 musculus male 1, biological rep1, brain
Relations
BioProject PRJNA103021

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE9338_RAW.tar 257.1 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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